Intrinsic role of FoxO3a in the contraction of CD8+ T cell response (110.14)
Bibliographic record
Abstract
Abstract CD8+ T cells undergo rapid expansion during infection with intracellular pathogens, which is followed by swift and massive culling of primed CD8+ T cells. The mechanisms that govern the massive contraction of primed CD8+ T cells are not clear. We show that the transcription factor Foxo3a plays a key role in the contraction, not expansion, of CD8+ T cell response against Listeria monocytogenes (LM). FoxO3a-mutant OVA-specific CD8+ T cells isolated during peak of response displayed reduced expression of pro-apoptotic molecules BIM and PUMA, and underwent reduced apoptosis during contraction phase in comparison to WT cells. A higher number of memory precursor effector cells (MPECs) were detectable in FoxO3a-mutant mice compared to WT mice during contraction phase. Furthermore, FoxO3a-mutant OVA-specific CD8+ T cells upon transfer into normal mice underwent highly reduced contraction. These results show for the first time that FoxO3a acts in a cell intrinsic manner to promote the culling of primed CD8+T cells during the contraction phase.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".