Endothelium‐dependent contractions in the carotid artery of young adult spontaneously hypertensive rats are mediated by cyclooxygenase and markedly augmented by nitric oxide inhibition
Bibliographic record
Abstract
We have recently shown that ACh‐stimulated vasomotor activity in isolated PE‐precontracted common carotid artery (CCA) rings from young adult spontaneously hypertensive rats (SHR) involves a dose‐dependent relaxation phase from −9 to −7 LogM followed by a ‘re’‐contraction phase through to −4 LogM, whereas in normotensive Wistar Kyoto rats (WKY) only a robust relaxation phase existed. The objective of this study was to test the hypothesis that [ACh] >−7 LogM stimulates contractions in quiescent CCA from SHR but not WKY. Reference KCl contractions in CCA were similar between strains and across all drug conditions (0.9−1.0g). [ACh] from −9 to −4 did not elicit vasomotor activity in WKY CCA, nor did [ACh] elicit vasomotor activity in SHR CCA from −9 to −7; however, [ACh] >−7 stimulated a dose‐dependent contraction in SHR CCA reaching a plateau at −4 (0.16±0.03g). Endothelium denudation completely abolished these ACh‐stimulated contractions as did cyclooxygenase (COX) inhibition, whereas blocking endothelial nitric oxide (NO) synthase markedly increased the amplitude (0.61±0.08g) but not the threshold or sensitivity of the contractile response. These data demonstrate that only [ACh] >−7 LogM can stimulate contractions in CCA from young adult SHR (but not WKY) that are endothelium‐dependent, COX‐mediated, and powerfully modulated by the availability of NO. Research Support: HSFO and NSERC
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".