Role of human CEACAM5 and CEACAM6 in murine lung tumorigenesis
Bibliographic record
Abstract
C9 Human carcinoembryonic antigen (CEA or CEACAM5) and its close relative, CEACAM6, are often over-expressed in many cancers. While CEACAM5 and CEACAM6 have been shown to play a role in colon and pancreatic cancers, their relevance to lung cancer is presently unknown, although CEA is commonly used for diagnosis and prognostic evaluation of patients with cancers at this site. Transgenic mice expressing both human CEACAM5 and CEACAM6 in lung tissue (CEABAC mice) have been generated in FVB/N mice, which are prone to develop spontaneous lung tumors. Here we show that, although spontaneous lung tumors are far more prevalent in male than in female WT mice, in CEABAC mice the females selectively show a 5 to 7 fold higher lung tumor incidence than their WT counterparts, bringing the incidence above that of male mice. Mutations in K-ras, but not p53, can be detected in these lung tumors. The mechanism of this increase specifically in the female FVB/N mice is presently unknown. These results suggest a possible role of CEACAM5/CEACAM6 in human lung tumorigenesis which is female specific.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".