Background ophthalmological changes following subretinal injection in the brown Norway rat
Bibliographic record
Abstract
Purpose The purpose of the study was to evaluate the background changes associated with transscleral subretinal injection in Brown Norway (BN) rats Methods Fifteen BN rats received a bilateral transscleral subretinal injection of saline at a volume of 6 μL while under isoflurane anesthesia. The eyes were examined by slit lamp and indirect ophthalmoscope the day following injection and 1, 2, 3, 4, 8 and 12 weeks post injection Results Procedure‐related changes included the following observations: Transient corneal opacities occurred in 16/30 eyes that were considered related to the anesthesia. Cataracts developed in 5/30 eyes associated with lens trauma at the time of dosing. Slight vitreous hemorrhages occurred post dose in 28/30 eyes, resolving in all but 2 eyes by 4 weeks. An area of focal depigmentation of the retina/choroid or white focal retinal opacity was seen at the needle insertion site at the retina in 22/30 eyes, resolving by 4 weeks for 13 eyes and persisting up to 12 weeks for the remaining 7. In the bleb itself, there were focal areas of irregular pigmentation in 13/30 eyes resolving in all but 2 eyes by week 4. The remaining 2 persisted up to week 12. This was considered secondary to the physical neuro‐retinal separation caused by the bleb formation. Slight retinal/choroidal hemorrhages were also seen at the injection site in most eyes up to week 4 Conclusions In conclusion, transscleral subretinal injection in BN rats generally resulted in slight ocular trauma that resolved in most eyes by 4 weeks post injection. It is important to take these changes into account when designing the study and evaluating therapeutics administered by this dose route.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".