Fluticasone propionate inhaled 3 hours after an early allergic reaction partially inhibits the late phase reaction
Bibliographic record
Abstract
Introduction: Inhalation of 800μg budesonide (AJRCCM 1994;149:1447) or 500μg beclomethasone (JACI 1993;91:1163) upon resolution of the allergen-induced early phase response inhibits the late phase asthmatic response (LAR) by 39% and 70%, respectively. This has never been tested for the highly lipophilic corticosteroid fluticasone propionate (FP). Methods: This randomized double-blinded, placebo-controlled, 3-way crossover study ( NCT00716963 ) was conducted in 6, mild allergic asthmatic patients with a documented dual bronchoconstrictor responses to inhaled allergen. Patients underwent 3 allergen challenges separated by 14 day washout periods. Patients inhaled placebo, 250μg or 1000μg FP at 3 h after allergen challenge, and the magnitude of the LAR was measured at regular intervals until 7 h post challenge. Sputum induction was performed before, 7 h and 24 h post challenge, and methacholine PC20 measured before and 24 h post challenge. Results: Five patients completed the study. 250μg and 1000μg FP significantly attenuated the LAR compared to placebo; the mean (SD) maximum% fall in FEV1 during the late response was 25.2% (6.2) with placebo, 15.1% (7.1) with 250μg FP (p=0.01), and 18.3% (8.2) with 1000μg FP (p=0.04). Inhibition of the LAR was 40% and 27% for 250μg and 1000μg FP, respectively. There was no effect of FP on allergen-induced sputum eosinophils, with a trend for reduced AHR which was not statistically significant. Conclusions: FP given three hours after allergen challenge attenuates the LAR, demonstrating that this lipophilic corticosteroid reduces the LAR when administered after allergen exposure. This research was conducted with support from AstraZeneca.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".