The Eye is the Window to the Kidney and Brain

Diabetic retinopathy and age-related macular degeneration are leading causes of blindness among older adults. Both conditions are more prevalent among those with chronic kidney disease (CKD). However, few if any previous examinations of CKD and visual impairment (VI) have been conducted. This gap in knowledge is filled by Wong et al., 2016Wong C.W. Lamoureaux E. Cheng C.Y. et al.Increased burden of vision impairment and eye diseases in persons with chronic kidney disease — a population-based study.EBioMedicine. 2016; 5: 193-197Summary Full Text Full Text PDF PubMed Scopus (45) Google Scholar in their article published in this issue of EBioMedicine. The prevalence of VI and associations between CKD, VI and other major ocular diseases are reported for Asian adults between 40 and 80 years of age participating in the Singapore Epidemiology of Eye Disease (SEED) Study between 2004 and 2011 (n = 9434). Chronic kidney disease (estimated glomerular filtration rate < 60 mL/min/1.73 m2) was defined using the Kidney Disease Outcomes Quality Initiative (KDOQI) Work Group definition and diagnosis of VI and other major ocular diseases were based on comprehensive ophthalmological examination. The prevalence of VI and any ocular disease were significantly higher in those with CKD (36.1% and 84.7%) than in those without (12.9% and 54.3%). Moreover, CKD was associated with significantly higher risk of VI, any ocular disease, cataracts, any retinopathy and diabetic retinopathy after adjustment for potential confounders (odds ratios ranging from 1.24 to 1.94). This paper makes a valuable addition to the literature because adequate vision is fundamental to quality of life and many forms of blindness are treatable and preventable (Wong et al., 2016Wong C.W. Lamoureaux E. Cheng C.Y. et al.Increased burden of vision impairment and eye diseases in persons with chronic kidney disease — a population-based study.EBioMedicine. 2016; 5: 193-197Summary Full Text Full Text PDF PubMed Scopus (45) Google Scholar). One impressive aspect of the study, apart from the very large sample, is that multiple eye disease outcomes are presented in a single study (i.e., those previously mentioned as well as glaucoma). The benefits of comparing different outcomes within the same study, as compared to different studies using different samples and methods, are obvious. The selection and modeling of covariates to adjust for confounders reflects the authors' understanding that “the high occult burden of ocular disease may be explained in part by risk factors common to both eye and kidney disease” (Wong et al., 2016Wong C.W. Lamoureaux E. Cheng C.Y. et al.Increased burden of vision impairment and eye diseases in persons with chronic kidney disease — a population-based study.EBioMedicine. 2016; 5: 193-197Summary Full Text Full Text PDF PubMed Scopus (45) Google Scholar). The models represent an exhaustive list of theoretically and clinically relevant cardiovascular disease covariates. We were, however, disappointed in the lack of any variable indexing inflammation (e.g., C-reactive protein, but see Table 1 for an extended list), an important mechanism underlying CKD and ocular disease, particularly among those with diabetes mellitus. This is discussed by Wong et al., 2016Wong C.W. Lamoureaux E. Cheng C.Y. et al.Increased burden of vision impairment and eye diseases in persons with chronic kidney disease — a population-based study.EBioMedicine. 2016; 5: 193-197Summary Full Text Full Text PDF PubMed Scopus (45) Google Scholar, although they did not list it as a limitation of their study. Additionally, late stages of CKD were examined in relation to VI and ocular diseases without considering physiological complications of treatment that have been previously identified (Murray, 2008Murray A.M. Cognitive impairment in the aging dialysis and chronic kidney disease populations: an occult burden.Adv. Chronic Kidney Dis. 2008; 15: 123-132Summary Full Text Full Text PDF PubMed Scopus (294) Google Scholar, Chelala et al., 2015Chelala E. Dirani A. Fadlallah A. et al.Effect of hemodialysis on visual acuity, intraocular pressure, and macular thickness in patient with chronic kidney disease.Clin. Ophthalmol. 2015; 9: 109-114PubMed Google Scholar).Table 1Inflammatory markers identified in the cardiovascular literature.Categories of inflammatory markersInflammatory markersAcute-phase reactantsC-reactive proteinFibrinogenSerum amyloid AAdhesion moleculesVascular cell adhesion molecule-1P-selectinIntracellular adhesion molecule-1E-selectinCytokinesInterleukin-1βInterleukin-6Interleukin-8Interleukin-10Monocyte chemoattractant protein-1Tumor necrosis factor-αOther MechanismsA2 phospholipasesErythrocyte sedimentation rateMatrix metalloproteinasesMyeloperoxidasePlacental growth factorWhite blood cell count Open table in a new tab Future studies will benefit from consideration of inflammation as a common precursor of ocular and kidney disease, especially in individuals with diabetes (Semeraro et al., 2015Semeraro F. Cancarini A. dell'Omo R. et al.Diabetic retinopathy: vascular and inflammatory diseases.J. Diabetes Res. 2015; 58260Crossref PubMed Scopus (277) Google Scholar). There is also a broader context for future studies that promises to tie the literature on visual and cognitive outcomes together. It is clear that CKD predicts significantly lower levels of cognitive performance, with the worst performance observed for those with the lowest levels of kidney function (Elias et al., 2009Elias M.F. Elias P.K. Seliger S.L. et al.Chronic kidney disease, creatinine and cognitive functioning.Nephrol. Dial. Transplant. 2009; 24: 2446-2452Crossref PubMed Scopus (152) Google Scholar, Elias et al., 2013Elias MF, Dore GA, Davey A. Kidney disease and cognitive functioning. In: Toyoda K, ed. Brain, Stroke and Kidney. Ronco C (Series Ed.), Contributions to Nephrology (vol. 179). Basal: Karger; 2013: 1–16Google Scholar, Davey et al., 2013Davey A. Elias M.F. Robbins M.A. et al.Decline in renal functioning is associated with longitudinal decline in global cognitive functioning, abstract reasoning, and verbal memory.Nephrol. Dial. Transplant. 2013; 28: 1810-1819Crossref PubMed Scopus (77) Google Scholar, Torres et al., 2016Torres R.V. Elias M.F. Seliger S. et al.Risk for cognitive impairment across 22 measures of cognitive ability in early stage chronic kidney disease.Nephrol. Dial. Transplant. 2016; (in press)Crossref Scopus (21) Google Scholar). Further, visual impairment has been associated with lower levels of performance on certain cognitive tests in the elderly (Dupuis et al., 2014Dupuis K. Pichora-Fuller M.K. Chasteen A.L. et al.Effects of hearing and vision impairments on the Montreal Cognitive Assessment.Neuropsychol. Dev. Cogn. 2014; 22: 413-437Crossref PubMed Scopus (186) Google Scholar). This is consistent with our finding that tests of cognition most sensitive to CKD are very often those which require adequate vision to complete (e.g., those indexing visual–spatial organization and memory) (Torres et al., 2016Torres R.V. Elias M.F. Seliger S. et al.Risk for cognitive impairment across 22 measures of cognitive ability in early stage chronic kidney disease.Nephrol. Dial. Transplant. 2016; (in press)Crossref Scopus (21) Google Scholar, Elias et al., 2009Elias M.F. Elias P.K. Seliger S.L. et al.Chronic kidney disease, creatinine and cognitive functioning.Nephrol. Dial. Transplant. 2009; 24: 2446-2452Crossref PubMed Scopus (152) Google Scholar). However, visual acuity and other indices of visual function are rarely reported or analyzed as confounders in cognitive studies. Application of the Wong et al. paradigm (Wong et al., 2016Wong C.W. Lamoureaux E. Cheng C.Y. et al.Increased burden of vision impairment and eye diseases in persons with chronic kidney disease — a population-based study.EBioMedicine. 2016; 5: 193-197Summary Full Text Full Text PDF PubMed Scopus (45) Google Scholar) to studies of cognition would help us understand the extent to which cognitive deficits in the elderly are, in part, a reflection of poor vision rather than cognitive impairment. The Wong et al. study (Wong et al., 2016Wong C.W. Lamoureaux E. Cheng C.Y. et al.Increased burden of vision impairment and eye diseases in persons with chronic kidney disease — a population-based study.EBioMedicine. 2016; 5: 193-197Summary Full Text Full Text PDF PubMed Scopus (45) Google Scholar) is of epidemiological and clinical significance. The prevalence of VI as indexed in those with CKD is 36%, versus 13% among those without CKD. In the former, the odds ratio of VI among individuals without diabetes was 1.11 compared to 1.80 among individuals with diabetes. Moreover, the odds ratio of retinopathy among individuals without diabetes was 1.45 compared with 1.95 among individuals with diabetes. This is unacceptably high risk given that CKD, diabetes and eye diseases are treatable and preventable. Screening for ocular diseases in those with CKD, especially individuals with diabetes, is warranted. More generally, the Wong et al. paper (Wong et al., 2016Wong C.W. Lamoureaux E. Cheng C.Y. et al.Increased burden of vision impairment and eye diseases in persons with chronic kidney disease — a population-based study.EBioMedicine. 2016; 5: 193-197Summary Full Text Full Text PDF PubMed Scopus (45) Google Scholar) tells us that eye is not only the window to the kidney, but also to the brain. The authors declared no conflicts of interest. Increased Burden of Vision Impairment and Eye Diseases in Persons with Chronic Kidney Disease — A Population-Based StudyThe burden of VI and eye diseases is high among persons with CKD. Our findings suggest that it may be useful to screen for ocular disease and VI in persons with CKD. Full-Text PDF Open Access

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