Pharmacotherapies for nicotine addiction in adults and adolescents
Bibliographic record
Abstract
The prevalence of tobacco use has declined substantially in the past few decades, yet it remains the leading cause of preventable death globally. Smoking frequency in adolescents is also alarming and is often associated with greater susceptibility to health problems in their adult lives. Unlike the extensive body of literature that exists for adults, research on smoking cessation approaches for adolescents is scarce. This review discusses current pharmacological and psychosocial interventions available for both adults and adolescents. Anti-smoking medications approved for adult smokers are either nicotine based (i.e., nicotine patch, gum, inhaler, nasal spray and lozenges) or non-nicotine based (i.e., sustained-release bupropion and varenicline), all of which improve abstinence by acting on nicotinic acetylcholine receptors (nAChRs) in the brain. Non-pharmacological interventions targeting the psychosocial aspects of smoking addiction include brief counselling, cognitive-behavioural therapy, motivational interviewing, contingency management, relapse-prevention strategies, social influence and mobile phone-based programs.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".