Bibliographic record
Abstract
Clostridium difficile infection in humans is on the rise and vaccine targets that will reduce both disease and colonization levels are needed. Potential vaccines comprised of C. difficile cell-wall polysaccharides PS-I, PS-II, and PS-III are being investigated in the Monteiro laboratory at Guelph. In this work, the discovery of mannan moieties in C. difficile is reported. The mannose units were present as end-groups [α-Man-(1→], 2-linked linear units [→2)-α-Man-(1→] and 2,6-linked branch-points [→2,6)-α-Man-(1→]. Within the limits of detection, no mannose residues were detected in the analysis of the growth media. Sporulating C. difficile preparations were observed to contain greater amounts of mannose. Campylobacter jejuni (C. jejuni ) is a food borne pathogen that is one of the leading causes of gastroenteritis in the world. Characterization of the surface polysaccharides is a crucial step in the development of a vaccine against C. jejuni infection. Knowledge about polysaccharide structure will also give insight into the function of bacterial surface and aid in conjugate vaccine development. In this study, the capsular polysaccharide of C. jejuni serotype HS:44 was investigated. Physico-chemical analysis of HS:44 capsular polysaccharide revealed that it was rich in heptose units.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".