Chronic intermittent hypoxia abolishes respiratory LTF in rat pups and enhances apnea frequency
Bibliographic record
Abstract
We tested the hypothesis that chronic intermittent hypoxia (IH) alters respiratory long‐term facilitation (LTF) induced by acute hypoxic episodes in newborn rats. Rat pups were exposed to normal room air (controls) or chronic IH (IH: O 2 levels cycled between 21% and 5% every 10 minutes for 1h; 1h normoxia, 24h/day) during postnatal days 1–10. To assess LTF, we measured minute ventilation (VE ‐ whole body plethysmography) in normoxia and during a recovery period of 2 hours following 10 acute hypoxic episodes. VE gradually increased (+23%) during recovery in controls, but decreased (−15%) in IH rats. In controls, frequency of apneas (≥2 missed breaths, measured before and at the end of recovery) slightly increased following acute hypoxic episodes (from 23±3 to 34±5 apneas/hour), while it dramatically increased in IH rats (from 26±4 to 61±6 apneas/hour). There was no gender‐specific effect. We conclude that in 10‐day old rats: i) LTF is present, ii) chronic IH abolishes LTF and iii) LTF appears to have a protective role against apneas. Neonatal apnea with IH may abolishe endogenous protective mechanisms, and contribute to increase apnea frequency in neonates. (FRSQ, CIHR, Sick kids foundation).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".