Abstract TMP117: Intracranial Dolichoectasia in Patients with Lacunar Strokes: The SPS3 Trial
Bibliographic record
Abstract
Background and Purpose: Intracranial arterial dolichoectasia (IADE) is a common finding in atherothrombotic strokes, but its relationship with lacunar infarcts is less certain. We investigated the prevalence of IADE and its correlation with risk factors as well as with recurrent stroke within the Secondary Prevention of Small Subcortical Strokes (SPS3) study cohort. Methods: The greatest diameter of the following arteries was measured on MRA: bilateral internal carotid artery (ICA), middle cerebral artery (MCA), vertebral artery (VA), and the basilar artery (BA). IADE criteria were a diameter of over 7.0 mm for ICA, over 4.0 mm for MCA, over 4.0 mm for VA, and over 4.5 mm for BA. BA elongation was assessed according to Smoker’s criteria. Results: Of the 3020 SPS3 participants, 2562 MRAs were assessed. Diameters were: ICA, 4.4 +/- 0.6 mm; MCA, 2.6 +/- 0.4 mm; BA, 3.4 +/- 0.7 mm; and VA, 2.4 +/- 0.7 mm. Of the measured participants 8% met criteria for IADE; 65% had IADE in a single artery, 28% in two arteries, and 7% in more than two arteries. Abnormality in either height of the bifurcation (66.7% vs. 4.6%, p<0.001) or lateral displacement (45.6% vs. 1.4%, p<0.001) of the BA was observed more frequently in patients with IADE than without. Conclusion: In this large and well characterized cohort of lacunar stroke patients, IADE was present in 8%, approximately half of whom demonstrated BA elongation. The relationship between IADE and incidence of recurrent stroke will be presented. Ongoing analyses from SPS3 will likely elucidate if IADE is a risk factor for stroke recurrence in lacunar stroke patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".