Record W2278147432 · doi:10.1212/wnl.0000000000002236

Effect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke

2015· article· en· W2278147432 on OpenAlexfundno aff

Grant Mair, Rüdiger von Kummer, Zoë Morris, Anders von Heijne, Nick Bradey, Lesley Cala, André Peeters, Andrew Farrall, Gillian Potter, Geoff Cohen, Peter Sandercock, Richard I. Lindley, Joanna M. Wardlaw, Colin Baigent, David Chadwick, Pippa Tyrrell, Gordon Lowe, Martin Dennis, Karen Innes, Heather Goodare, Graeme J. Hankey, Karl Matz, Michael Brainin, Gord Gubitz, Stephen Phillips, Stefano Ricci, Antonio Araúz, Eivind Berge, Karsten Bruins Slot, Anna Członkowska, Adam Kobayashi, Manuel Correia, Phillippe Lyrer, Stefan T. Engelter, Veronica Murray, Andreas Terént, Bo Norrving, Per Wester, G.S. Venables, Andrew Farrall, Robin Sellar, Alessandro Adami, Phil White, Andrew M. Demchuk, Matthew Adams, Bernard Yan, C Blank, Helen Bowler, Cara Doyle, Keith Endean, K. Harkness, Edward F. Parker, Marc Randall, Christine Roffe, Naveed Ahmad, Anand Arora, Susan V. Brammer, J Chembala, B. Davies, Sarah J. Ellis, Richard H. Epstein, K. Finney, Chris Jackson, Changez Jadun, Ruth Kinston, Holly Maguire, I Memon, Indira Natarajan, Michael Poulson, R. Sanyal, Sheila Sills, ANNA E. M. VREEBURG, Elizabeth Ward, Rustam Al‐Shahi Salman, Richard Davenport, Peter J. Hand, Simon P. Hart, Sarah Keir, Mary Joan MacLeod, L McKinlay, Hazel Milligan, E SANDEMAN, Jennifer Stone, Cathie Sudlow, Peter R. Taylor, C Warlow, William Whiteley, A. Olufemi Williams, M. Brown, B.S. Athwal, Vanessa Bassan, Neelima Bhupathiraju, John V. Bowler, Charles Davie, David Doig, Renuka Erande, Stephen Gilbert, Lionel Ginsberg, Nan Greenwood, Simone M. Gregoire, Nicola Harding, Nicholas Losseff, Robert Luder, Nathalie Passeron, Richard Perry, Philip Rayson, Robert Simister, Simon Stone, James Barrett, H Aitken, Sarah Cherian, Ryan L. Davis, Susan Downham, L Godd, V. L. Gott, David José, Victoria Little, David Lowe, L Luxford, Matthew T. McGrory, Paula Owings, N Price, John Richards, Graeme Sangster, Julian Sherlock, Susan Vargese, Ian Wakefield, Pauline Weir, Paul Guyler, T Attygale, Susan M. Chandler, Lucy Coward, S Feasey, C Khuoge, Thayalini Loganathan, Sascha E. Martin, Anne Sibley O'Brien, D Sinha, Vanessa R. Thompson, Sharon Tysoe, Richard Walsh, Kerstin Metcalf, Jeffrey I. Cochius, Ryan P. Fulcher, Nisal Gange, Catherine Green, Jacqui Jagger, M Lee, Phyo Kyaw Myint, John F. Potter, Garth Ravenhill, Stephanie Shields, Naval Shinh, Tom Staunton, Eleanor Thomas, Wendy A. Woodward, P. H. L. WORTH, N. Wyatt, W Sunman, Philip M. Bath, Peter H. Berman, Judith Clarke, Catherine Gaynor, Fiona Hammonds, Rowan Harwood, Kate M. Mitchell, Soumyabrata Munshi, Sarah Pacey, Ashit Shetty, Nikola Sprigg, H Stear, G. Mani Subramanian, Andrew K. Wills, Anthony Rudd, Heinrich J. Audebert, Ajay Bhalla, Jonathan Birns, Rasheda A. Chowdhury, Gillian Cluckie, Ian G. Davies, Charlotte Gibbs, Patrick Holmes, Nicola J. Mitchell, Francesca Schiavone, Eleanor White, Meredith T. Yeung, A. Mehrzad, Vidyagauri P. Baliga, Lewis Burnside, Bernard Esisi, Jennifer Kent, Orr P, David Stead, Emma Wayman, R Durairaj, C Cullen, Rohit Kumar, H Martı́n, Dermot T. McDowell, Alka Sharma, Victoria Sutton, Robert M. White, Thomas A. Hughes, Khalid Ali, J. Anderson, Katherine Baker, K Bethune, K Bethune, M Booth, M. Cossburn, Sophie Halpin, M D Hourihan, E. Neil G. Marsh, K. J. Peall, Rebecca Powell, Hamsaraj Shetty, M. Wardle, Michelle A. Williams, K Muhiddin, J. Beavan, M Clarke, R Donneley, Simon Elliott, Peter Fox, Peter H. Gorman, Margaret Harper, M Mangoyana, Lisa Mills, L Wright, Liz Warburton, Jean‐Claude Baron, Peter Barry, Diana J. Day, Teresa Harold, Jennifer Mitchell, Eoin O’Brien, J Rycarte, M Turnham, Geoffrey Cloud, L Y Lois Choy, Ben Clarke, C. J. Griffin, Omid Halse, Ifan Jones, Fiona Kennedy, Uzma Khan, Russell E. Lewis, Alison Loosemore, Caroline Lovelock, B. Moynihan, J. N. O'Reilly, Anthony Pereira, Martin Punter, Preston B. Rich, Debbie Rolfe, Martin James, James Bell, A Bowring, Lucy Boxall, Julie Cageao, H. Eastwood, Salim Elyas, Fiona Hall, S. Harries, Anthony Hemsley, Shaun P. Jackson, Sharon Keenan, P Mudd, Aravind Sekhar, W. David Strain, Jane Sword, Nicola Wedge, M F Bruce, Anu Joyson, Matthew W. Kemp, K McMullan, Joanne Reid, Olive J. Robb, Joan Webster, Steven B. Wilkinson, Parag Sharma, P.J. Bentley, Helen E. Jenkins, Anindya Kar, Teviah E. Sachs, David Cohen, Rajaram Bathula, Joe Devine, Mushiya Mpelembue, David Hargroves, Ibrahim Balogun, Luke Cowie, Andrew D. A. Maidment, D.A.J. Rand, J. Rowe, Hannah Rudenko, David Smithard, L. Randall Wray, J. Paterson, Julia Brown, J R Hampton, S Jamieson, Richard J. Rose, A P Volans, Kausik Chatterjee, G D Abbott, Roger H. Brookes, C. Hilmon Castle, Christine Kelly, S Leason, Arumugan Nallasivan, A. K. Sen, David Collas, Maurice H. Cottle, Nizar Damani, Patricia Jacob, Deepali Oza, Anthony Kenton, Naghme Adab, Lynley Aldridge, Holger Allroggen, Yvonne Brown, Rebecca Cross, Leanne Galvin, Kanjaksha Ghosh, A. Grubneac, A Lindahl, Hemal Mehta, M. A. Pritchard, Clive A. Randall, Pradeep Ray, Artenca Shehu, S Thelwell, D Jenkinson, Toby Black, Olivier David, Joseph Kwan, A.G. Orpen, Catherine Ovington, Divya Tiwari, Zaheer‐Ud‐Din Babar, Ahamad Hassan, Alanah Bailey, John Bamford, Caroline Bedford, Ruth Bellfield, Jane Cooper, Louise Dunsmure, Jill Greig, Matt J. Keeling, L. Mandizvidza, James J. Rankine, Elved Roberts, Peter Wanklyn, Tom R. Webb, Sheara T. Williamson, John Coyle, Stephen C. Crane, C. Croser, P L Duffey, Rachel Evans, Elizabeth Iveson, G Kitching, M. Porte, Christopher Rhymes, David Barer, Megan Armstrong, Masooma Zainab Bokhari, Tim Cassidy, Beverley McClelland, G Gunathilagan, P Dolke, Sumeet Jain, Sarah Jones, Ludie E Rosser, Giles Thomas, Christopher J. White, P. S Sanmuganathan, Carl L. Scholtz, Elaine Stratford, Martin O’Donnell, H Goddard, Graham Hoadley, James P. Howard, Simon Leach, James McIlmoyle, Antony Stewart, Alastair J. Strain, Farhad Huwez, Peter Croot, Narasimha Gadi, Nhlanhla Mguni, Udayaraj Umasankar, G E Mead, B. Chapman, A. Coull, A Kinnear, Bernice E. Morrow, F D Morrow, D Ames, Julie Ball, S Bannerjee, Jeremy Chataway, Khalid Rashed, C Buckley, Denise Donaldson, David Hayward, C. J. Lawson, Lakshmanan Sekaran, Kiranjit Bharaj, Frances Justin, G Jutlla, Daniel Chinyama Phiri, S. Sethuraman, Mandy Tate, David Sandler, Peter J. Carr, Gareth‐Rhys Jones, Jennifer Lyons, Katherine Warren, Lalit Kalra, Adrienne L. Davis, Józef Jarosz, Dulka Manawadu, L. Sztriha, Dinesh Chadha, Angus Holford, Paul Willcoxson, Louise Shaw, Denise Button, Andrew Cunningham, Lindsey Dow, J Dutson, Toby Hall, Christian Hardy, Nicola Jakeman, Philip Kaye, B. Madigan, Kevin O’Brien, D.J. Pressdee, Michael R. Price, Lee Robinson, Carly Taylor, Daniel Williamson, D Sandler, J. G. McCormack, Cathy Stretton, P.M. Earnshaw, Suzanne Bruce, Catherine Church, Shashvat M. Desai, Min Myint, N.J. Watt, Christopher Price, Hillary L. Graham, Rachel Lakey, Keith Mitchelson, Peggy Murphy, Lorenzo Ball, S. Caine, Jon Dovey, Jeremy Hughes, K Dizayee, Andrew Brown, T Chattopadhyay, J. CHEETHAM, Helen Cochrane, Anindita Datta, M Datta-Chaudhuri, Chris Fox, Darren Kılroy, Suresh Krishnamoorthy, François Lévy, SamruddhiSwapnil Metha, P Ngoma, Balasubramanian Venkatesh, Roshani Gautam, Neil C. Henderson, Mark Jones, Sue Murphy, Geoffrey Spurling, Ivan Wiggam, Christopher A. Boyd, Ken Fullerton, Peter Gray, Margaret F. Kinnaird, S MacNair, Catherine Morgan, Machar Reid, Sheral Raina Tauro, Shankar Loharuka, Damian Balmforth, P Cox, Glyn Fletcher, A Ledger, Aravind Manoj, M. C. Wilkinson, D. Nicholl, Shona Clegg, S Hurdowar, Shahid A Kausar, Kelsey B. Law, Archana Singal, S. Sturman, Patrick Gompertz, J Evanson, Andrew Farrell, Anthi Petrou, Kari Saastamoinen, Afraim Salek‐Haddadi, R Yadava, J.R O’Connell, Helen M. Brew, S Butler, Susan E. Crawford, C Gray, David J. Gulliver, N. G. Majmudar, Ricky O’Brien, Mohd Lateef Wani, Lynne Dacey, Lucy Davies, David C.H. Harris, Terry E. Jones, Sharon Storton, S Punekar, Amy Ashton, S Duberley, Hedley Emsley, C. C. B. Gilmour, Bindu Gregary, Leaetta M. Hough, Saji Philip, Siddhartha Wuppalapati, K. Fotherby, Patricia Bourke, D F D'Costa, Kelly Kauldhar, Dominic Y. Leung, Rebecca Lodwick, Shirley McBride, David Morgan, M Qaiyum, Gurminder Sahota, M Srinvasan, N Chuter, L Garrad, Max Hookway, Simone Ivatts, Gregory D. Kennedy, Khaled Darawil, L Al Dhahirl, Sreeman Andole, Mirza Rafi Baig, Parveen Dugh, Kevin Dunne, Hazel Kariuki, Mohammad Faizan Khan, SM Rathnayaka, Maxine Power, Kevin Dynan, James Finnerty, Anthony P. Heaney, Conrad Leonard, K McKnight, J R A Turkington, Belinda Wroath, Bhupesh Dewan, Seonaidh Cotton, Mark Gardiner, Tracee M. Saunders, B Vincent, Don Sims, P. G. Guest, Elizabeth A. Jones, J Savanhu, Rebecca Tongue, M Willmot, D. Eveson, Suzanne Dawson, Martin Dickens, Martin D. Fotherby, Rod W. Hunt, Sara Anees Khan, Tarun Kumar, Reginald Marsh, Amit Mistri, Thompson Robinson, John F. Thompson, Prasanna Aghoram, T M Daniel, Michelle Gatehouse, S Hussein, Anne Jackson, T Shanganya, E Strachan, Grace Tan, Bella Richard, S Hanson, Shakayla V. Mosely, Hayley Reed, Rushika Saksena, Stephen C. Cook, D Demuran, M Keating, Richard Needle, Vigi Paramsothy, Andrea Sebastian, Rangasamy Sivakumar, Alison C. Wright, Rebecca Grue, Elisa M Barberan, C. Dickson, C. G. Douglas, J. A. JELLICOE, Tracy Marsden, Joseph Priestley, Esther Quick, Catherine Sherrington, Amrinder Singh, Stewart Smith, Julia Stevens, Pippa Tyrell, J Wainwright, M E Ardron, Janet Birchall, Raj Shekhar, C.G. BARSTED, S Coleman, Sophie Fletcher, James E. Graham, Alastair M. Buchan, Janice L. Hinkle, J. Kennedy, Mark Westwood, Azlisham Mohd Nor, Steven Allder, Benjamin Hyams, Andrea Pace, Enoch Orugun, C Brewer, Lawrence Huntley, R Jolly, Charlotte Summers, K Sharobeem, J Khaira, John F. Leahy, Eimear Linehan, Gregory Moore, James Rizkalla, James S. Wilkinson, David T. Kelly, Christian Hilaire, Olayiwola Otaiku, Lynne Connell, G Delaney-Sagar, Gabriel James, Lynn Lomax, D J Matthew, Judy M. Simpson, H Whittle, Samuel N Sanmuganathan, Sally Burrows, Asif Mahmood, Giles Durward, Stephanie Barker, Jeffrey P. Cantle, Pamela Crawford, Stephen Evans, Vanessa Pressly, N. Weir, Vera Cvoro, K McCormick, Joshua N. Bembenek, Marta Bilik, Grzegorz Chabik, Wojciech Czepiel, Justyna Dzierka, Marcin Głuszkiewicz, Katarzyna Grabska, Barbara Janus-Laszuk, Julia Jędrzejewska, Tomasz Litwin, Adam Oskedra, Anna Piórkowska, Marta Skowrońska, Agnieszka Śliwińska, Urszula Stepien, Piotr Sobolewski, Agnieszka Gajewska, Marcin Grzesik, Renata Hatalska‐Żerebiec, Irena Łabudzka, Batista Rafael Loch, A Medrykowska, Marta Sledzińska, Andrzej Sobota, Wiktor Szczuchniak, G Wolak, I Zdyb, Walenty M. Nyka, Dariusz Gąsecki, Kamil Chwojnicki, Anna Gójska, Bartosz Karaszewski, Grzegorz Kozera, Mariusz Kwarciany, Mariusz Nowak, M Swierkocka-Miastkowska, Sebastian Szczyrba, Magdalena Wiśniewska, E Wnorowska, Peter Richter, Anna Bochyńska, M. Chahwan, Ałła Graban, Radosław Rola, Anna Stępień, Bogdan Brodacki, Małgorzata Grotowska, Jerzy Kotowicz, J Staszewski, Jarosław Świstak, S Zaloga, Jan Stoiński, K Czajkowaka-Fornal, Paweł Czubak, Agnieszka Kaczor, Jenna Kraska, E Nowakowska-Sledz, J Ozdoba-Rot, Emilia Zawadzka, Małgorzata Fudala, Darcy L. Adamczyk, Waldemar Brola, I Guldzinska, Krystian Kałużny, Marta Kucharska-Lipowska, M Mosiolek, Maciej Polewczyk, Mateusz Ziomek, Grzegorz Opala, Michał Arkuszewski, M Kudlacik, Pawłowska Małgorzata, Maciej Świat, Urszula Fiszer, Sabine Cenciarelli, Alessandro Barilaro, R Condurso, F. Coppola, Salvatore Dioguardi, E. Gallinella, A. Mattioni, C. Menichetti, Federica Casoni, M. Bacchelli, Milena Cavazzuti, Marcella Malagoli, Andrea Zini, G Benemio, Maria Grazia Celani, ROSITA ALLEGRUCCI, V Bondo, S Cupella, Lucy Guerra, Simona Donati Guerrieri, C Ottaviani, Enrico Righetti, Carlo Riccardo Rossi, Nicola Sacchi, Matteo Scucchi, V Stefanini, T Mazzoli, A Bigaroni, Laura Greco, Robert Paris, Paolo Parise, Alfonso Ciccone, Luciano Silveira Basso, R. Causarano, Paola Doneda, Elisa A. Ferrante, A Gatti, Angelo Guccione, Alberto Lo Gullo, F. Imbesi, S. Jann, R Marazzi, E Moro, Cristina Motto, Denise Parodi, Alessandro Protti, Marco Riva, A Rosiello, Ignazio Santilli, Roberto Sterzi, Pietro Tiraboschi, G. Venturelli, Francesco Iemolo, R. Campagna, Gian Marco Campagnolo, Alisia Carnemolla, N D'Apico, Gabriele D'Asta, S Giannarita, Alessio Giordano, E Sanzar, E. Bottacchi, Susanna Cordera, Giovanni Corso, Marco Di Giovanni, G Giardini, C Lia, T Meloni, Massimo Pesenti Campagnoni, P. Tosi, Gianluca Rossato, Teresa Zuppini, G. Procaccianti, T. Sacquegna, Claudia Gandolfo, Maurizio Balestrino, Chiara Bruno, Lucio Castellan, Massimo Del Sette, Angela Ferrari, Cinzia Finocchi, Nicoletta Reale, D Rizzi, L Benedetti, C. Capellini, E. Carabelli, E Cibei, Massimiliano Godani, Gloria Guariglia, E Landini, Antonio Mannironi, B Nucciarone, Stefano Parodi, Sara Tonelli, E Traverso, Domenico Zito, Pierluigi Brustenghi, Francesco Corea, O Flamini, S Lolli, G Pelliccia, Renato Pietro Ricci, S. Stefanucci, Mauro Zampolini, Domenico Consoli, Franco Galati, Paolo Postorino, G Rinaldi, E Carapelle, G. Grilli, Maria Guido, Luigi Maria Specchio, N Checcarelli, Gianfranco Borin, Luca Chiveri, Raffaella Clerici, Elisabetta Corengia, Lorenza Gandola, P. Garavaglia, Mario Guidotti, Alberto Martegani, M. Mauri, Francesco Muscia, F. Raudino, F Chiodo Grandi, Alessio Bratina, Nicola Carraro, Marina Gaio, Alberto Granato, Nadia Koscica, Marcello Naccarato, Vittoria Maria Sarra, Patrícia Schincariol, Cristina Vilotti, Z Zugna, D Idone, Cristian Bonato, E De Angelis, A. Forgione, Marco Gambera, F. Recchia, Stefano Tamburin, P. Tinazzi Martini, Giampietro Zanette, Spoleto S Grasselli, Giancarlo Agnelli, A Andrea, A Billecia, Valeria Caso, V.A. Cassó, Ramírez Romero Fabiola, Pietro Fanelli, Maurizio Paciaroni, Bracarda Sergio, M Vemti, M. Silvestri, L Altarini, A Bonfante, M Bonornetti, B Costa, N. D'Attoma, Federico Frattini, Richard Niego, D Rafaele, Valerie Ravenna, M. Turazzini, E Lundström, Li Jönsson, Ulf Söderström, A Alvelius, I. Dalenbring, N Greilert, M Hallberg, A Heijne von, Eva Isaksson, H Kumpulainen, Ann Charlotte Laska, Anders Lundström, Christopher J. Martin, Josephine Muhrbeck, Erik Näslund, N Ringart, Elisabeth Rooth, R Undén, Paul Waldenström, M Esbjörnsson, Michael Petranek, B Cederin, Eric Bertholds, A.C. Elgasen, Torsten Johansson, B Witteborn, Małgorzata Kwiatkowska, Erika Gustafsson, Torbjörn Norén, Jan Sääf, Jörg Teichert, Maria Bertilsson, S Nilsson, S Oestberg, Lennart Welin, K. Fredricson, L Pehn, Joakim Hambraeus, I. Lonn, Bo Höjeberg, A Adolfsson, M Anzen, Tyler Wallen, R Schloenzig, Pontus Söderström, Ann Wennerberg, F Buchwald, Kasim Abul‐Kasim, A Berkeskold, Johan Petersson, E Poromaa, Rolf Backlund, Anna Sjöström, B Hedström, E Campbell, Karl-Erik Johnsson, Björn Karlsson, N Lekokotla, Camilla Lundahl, Anette Risedal, Peter E. Sandgren, Ann‐Marie Svensson, S Bysell, Erno Smedberg, A Vestberg Bysell, Vilhelm Sjögren, B Högvall, G Andsberg, Tobias Cronberg, A. Lindgren, H Wannberg, F Ax, L Nyren, Jennifer E. Sanner, Hedvig Andersson, F Andler, S Holmgård, Rolf Johansson, I Magnussan, Kristin Nilsson, Johan Rådberg, Bent Indredavik, H Ellekjær, Ann Elisabet Østvik, G Rohweder, Dirk Steckhan, J Storvold, Y Rønning, Rune Aakvik, G Knutsen, Mads Henrik Strand Moxness, Renate Pettersen, Torgeir Bruun Wyller, Carl-Mattheis Wahl, O. H. Iversen, Stein Harald Johnsen, B Norderhus, L. H. Steffensen, Eva Stensland, T Asak, Jan Aaseth, T Røtnes, Jon Arne Sparby, S Wetterhus, Hans Hallan, A Aardal, T Graven, H Hansbakk Skjetne, Bjørnar Klykken, Karin Lindqvist, Alain Tommy, Tora Torgersen Engstad, Margareth Aarag Antonsen, Radoslav Bajic, W Fønnebø, Samuel Hykkerud, I Lyngmo, Audhild Nyrnes, Sigbjørn Rogne, Steven A. Sparr, O Kildahl-Andersen, Karen E. Pedersen, H Ulrichsen, O Skogen, I Alnes, R Hukari, Y M Seljeseth, P.O. Vadset, Brynjar Fure, H Ihle-Hansen, N. Johnsen, Lori J. Kornberg, S. Schüler, Mathis Heibert, Marja-Liisa Lillebø, O Aasen, I Eskeland, Torill Hamre, Sølvi Kristine Øyen Hareide, H. Helset, Kristoffer J. Kolnes, Bottolf Lødemel, Helge Ose Velle, S Reite, Elin Osvik Velle, Rohan Grimley, Elizabeth Ahern, Christine Cocks, Michael J. Courtney, R Devin, J. A. ENDACOTT, C. P. Fawcett, Val Harrington, Chris Johnston, M Koltermann, Scott A Murray, Kimmie Ng, George Styles, A Tampiyappa, Christopher Levi, Kevin Kien Hoa Chung, Leigha Dark, Mike Evans, Yash Gawarikar, Enda Kerr, Alayna E. Loiselle, Ferdinand Miteff, Angela Moore, William T. O’Brien, Mark Parsons, Debbie Quain, Angela Royan, Matthew Russell, Neil J. Spratt, J Sturm, D Crimmins, D. V. Griffiths, P Kavelieros, John Kinsella, Atul Malhotra, B. J. O’Brien, Alexander Schütz, M Webb, Sonia Whyte, V. Zenteno, Andrew Bleasel, Nicholas J. Cordato, Andrew Duggins, Victor S.C. Fung, L. Gomes, Nigel Ingham, James E. Ip, Peter Landau, John G. Morris, Steve Vucic, Anne Claxton, N. K. Lillywhite, Christian J. Lueck, C. J. Andrews, G Danta, Chandan Krushna Das, Isabel Harvey, A. Hughes, Craig McColl, Aileen Oon, R R Tuck, Stephanie H. Read, Monica Badve, Mary L. Broad, Greg Cadigan, H. Dwight Cavanagh, Jonathan B. Chalk, D Copsinis, K. Etherington, R Henderson, R. Hull, John D. O’Sullivan, Jeyaraj Pandian, Lesley Ross-Lee, M. Amico Roxas, Nomaan Sheikh, G. Skinner, Andrew Wong, Helen M. Dewey, Amy Brodtmann, Geoffrey A. Donnan, Maarit Karonen, Henry Ma, Thomas A. Mulcahy, S. Petrolo, Laura Walker, David Young, Jose Zavala, Mark J. Thieben, Christopher Harris, Mechthild Krause, Stuart Lane, Hyunmi Park, Mohamed Shaffi, Jeremy Wood, Christopher Bladin, Aaron J. Buckland, Karen Coughlan, Bronwyn Coulton, Amanda Gilligan, P Lee, S Mullen, Zev Ross, Poh Sien Loh, Cassandra Szoeke, M Silva, F Afonso, Joseph Gabriel, Pedro Guimarães, Ana Graça Velon, Miguel Castelo‐Branco, Francisco Moniche Álvarez, Vanessa Duarte Branco, Cristina Coxo, P Goulao, Danilo Marques Leal, S Morgado, Rogério Carvalho de Oliveira, FRANCISCO JEAN DIEGO DE ABREU PAIVA, Ana Maria Rodrigues, M Simoes, G. Lopes, Thaís Gomes de Almeida, Maria Regina Alves Cardoso, J. M. Chaves, Carlos Correia, Joana Damásio, Rui Felgueiras, João Pinto Pereira, Assunção Tuna, Carlos Ferreira, Elaine Lourenço, Álvaro Machado, Ricardo Maré, J. Rocha, Georg‐Christian Funk, Veronika Reiner-Deitemyer, Jéssica Tonin Ferrari, Agathe Flamm-Horak, Gerald Gruber, R Rattinger, Wolf Muellbacher, D Doppelbauer, R Kalchmayr, Wolfgang Schima, Thomas Wieser, M Zart, Philippe Lyrer, Leo H. Bonati, Felix Fluri, Susanne Müller, Ernst‐Wilhelm Radue, A Tiemessen, Lucas Walz, Florian Weisskopf, Stefanie Wetzel, Alexander Luft, Daniel Fetz, Benjamin Hertler, Athina Pangalu, G Gubitz, P. S. Boulton, J Jarrett, J Moeller, Luiz E. Bermudez, Juan Calleja, Roxanna M. García

Bibliographic record

VenueNeurology · 2015

Typearticle

Languageen

FieldMedicine

TopicAcute Ischemic Stroke Management

Canadian institutionsnot available

FundersMedical Research CouncilH. Lundbeck A/SChest Heart and Stroke ScotlandNational Health and Medical Research CouncilScottish Funding CouncilNorges ForskningsrådAcademy of Medical SciencesDalhousie UniversitySchweizerische HerzstiftungNational Research FoundationKarolinska InstitutetStroke AssociationStockholms Läns LandstingNational Institute for Health and Care ResearchNational Institute for Social Care and Health Research

KeywordsMedicineOdds ratioStroke (engine)CardiologyRandomized controlled trialInternal medicineFibrinolytic agentSurgeryTissue plasminogen activator

DOI10.1212/wnl.0000000000002236

Abstract

fetched live from OpenAlex

OBJECTIVE: To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3). METHODS: All prerandomization and follow-up (24-48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by masked raters. We assessed whether HAS grew, persisted, shrank, or disappeared at follow-up, the association with 6-month functional outcome, and effect of alteplase. IST-3 is registered (ISRCTN25765518). RESULTS: HAS presence (vs absence) independently predicted poor 6-month outcome (increased Oxford Handicap Scale [OHS]) on adjusted ordinal regression analysis (odds ratio [OR] 0.66, p < 0.001). Outcome was worse in patients with more (vs less) extensive HAS (OR 0.61, p = 0.027) but not in proximal (vs distal) HAS (p = 0.420). Increasing age was associated with more HAS growth at follow-up (OR 1.01, p = 0.013). Treatment with alteplase increased HAS shrinkage/disappearance at follow-up (OR 0.77, p = 0.006). There was no significant difference in HAS shrinkage with alteplase in proximal (vs distal) or more (vs less) extensive HAS (p = 0.516 and p = 0.580, respectively). There was no interaction between presence vs absence of HAS and benefit of alteplase on 6-month OHS (p = 0.167). CONCLUSIONS: IV alteplase promotes measurable reduction in HAS regardless of HAS location or extent. Alteplase increased independence at 6 months in patients with and without HAS. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that for patients within 6 hours of ischemic stroke with a CT hyperdense artery sign, IV alteplase reduced intra-arterial hyperdense thrombus.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000

metaresearch head score (Gemma)0.000

Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated

Candidate categoriesnone

Consensus categoriesnone

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Observational · Consensus signal: none

GenreCandidate signal: Empirical · Consensus signal: Empirical

Teacher disagreement score0.534

Threshold uncertainty score0.355

Codex and Gemma teacher scores by category

Category	Codex	Gemma
Metaresearch	0.000	0.000
Meta-epidemiology (narrow)	0.000	0.000
Meta-epidemiology (broad)	0.000	0.000
Bibliometrics	0.000	0.000
Science and technology studies	0.000	0.000
Scholarly communication	0.000	0.000
Open science	0.000	0.000
Research integrity	0.000	0.000
Insufficient payload (model declined to judge)	0.000	0.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016

GPT teacher head0.258

Teacher spread0.242 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.

Study designObservational

Domainnot available

GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations41

Published2015

Admission routes1

Has abstractyes

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