Bibliographic record
Abstract
Les introns de groupe II sont des introns autocatalytiques qui s'épissent des transcrits de pré-mARN, et liguent concurremment les exons flanquant. D'un point de vue évolutif, ils sont considérés comme les ancêtres des introns nucléaires eucaryotes et de leur appareil d'épissage, le spliceosome. On présume que le fractionnement d'un intron de groupe II ancestral a donné naissance aux cinq petits ARN nucléaires (snRNAs - U1, U2, U4, U5, U6) qui constituent le noyau catalytique du spliceosome. Cette hypothèse est supportée par la découverte d'introns de groupe II fragmentés qui s'épissent en trans dans certaines organelles. Nous avons soumis l'intron de groupe II Ll.LtrB de la bactérie Gram-positive Lactococcus lactis à un essai génétique basé sur le transposon EZ-Tn5, suivi par une analyse de conjugaison, afin d'isoler des introns tripartites capable de s'épisser en trans. En démontrant les premières variantes tripartites de Ll.LtrB in vivo, nous fournissons un support expérimental pour le lien évolutif entre les introns de groupe II et les snRNAs du spliceosome eucaryote.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".