The importance of aldosterone suppression in the restoration of cerebrovascular myogenic function in SHRsp during post stroke Captopril and Losartan treatment
Bibliographic record
Abstract
Treatment of Kyoto Wistar stroke prone spontaneously hypertensive rats (SHRsp) with Captopril (CAP) or Losartan (LOS) after hemorrhagic stroke (HS) restores pressure dependent constriction (PDC) in middle cerebral arteries (MCAs) . We assessed the importance of aldosterone (ALD) suppression during both treatments. Plasma ALD was elevated in SHRsp with HS over prestroke levels (3.9 ± 0.8 nM vs 0.15 ± 0.09 nM). SHRsp with HS were treated orally with 50mg/kg/day CAP or 35 mg/kg/day LOS for 28 days. During the last 10 days of treatment ALD (0.66 μg/hr) or vehicle was infused via an osmotic pump . CAP and LOS treatment suppressed plasma ALD (0.23 ± 0.07 and 0.075 ± 0.044 nM respectively), whereas supplementation elevated ALD (6.27±1.75 and 4.49 ± 0.80 nM respectively). ALD supplementation did not alter BP. After 28 days of CAP or LOS treatment, MCAs from SHRsp with HS (studied using a pressure myograph) regained PDC and the ability to constrict in response to protein kinase C activation (1μM phorbol dibutyrate) and elevated [K + ] o depolarization. ALD supplementation prevented these changes in CAP but not LOS treated SHRsp. Elevation in plasma ALD enhance the deterioration of myogenic function. We believe that poststroke treatment with LOS (vs CAP) promotes systemic beneficial effects that permit the restoration of cerebrovascular function even under conditions of where plasma ALD is elevated.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".