L. reuteri NCIMB 30242: The Sunshine Probiotic ?
Bibliographic record
Abstract
Background/Objectives Low serum 25‐hydroxyvitamin D (25(OH)D) is a risk factor for cardiovascular disease (CVD). Bile salt hydrolase (BSH) – active Lactobacillus reuteri NCIMB 30242 capsules have been shown to lower cholesterol and reduce sterol absorption; however their effect on fat soluble vitamins are unknown and the main objective of this study. Hypothesis The research hypothesis is that L. reuteri NCIMB 30242 capsules would not significantly alter serum fat soluble vitamins in a randomized controlled trial. Methods 127 subjects were randomized to consume L. reuteri NCIMB 30242 or placebo capsules over a 9‐week intervention period. Results Oral supplementation of L. reuteri NCIMB 30242 capsules did not result in reduced serum vitamins A, E and â‐carotene and unexpectedly increased 25(OH)D. Despite no differences in dietary intake (P>;0.05), subjects consuming L. reuteri NCIMB 30242 showed increased serum 25(OH)D over the intervention period by 14.9 nmol/l or 25.5%, which was a significant mean change relative to placebo of 17.1 nmol/l (P=0.005) or 22.4% respectively (P=0.011). Changes in 25(OH)D were negatively correlated with hs‐CRP (r = −0.208, P=0.023). Conclusions To our knowledge this is the first report of increased serum 25(OH)D with oral probiotic supplementation. L. reuteri NCIMB 30242 should be considered for improving vitamin D status in individuals with CVD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".