Helicobacter Pylori Infection is Associated with Worse Severity of Parkinson’s Disease (P3.018)
Bibliographic record
Abstract
OBJECTIVE: To study the impact of Helicobacter pylori (HP) infection on motor function, gastrointestinal symptoms, and quality of life in a large cohort of Parkinson Disease (PD) patients. BACKGROUND: Some studies have suggested that chronic Helicobacter pylori infection can aggravate the neurodegenerative process in PD, and targeted intervention could potentially modify the course of this disabling disease. DESIGN/METHODS: 102 consecutive PD patients underwent 13C urea breath testing and blinded evaluations consisting of the Unified Parkinson’s Disease Rating Scale (UPDRS) including “On”-medication motor examination (Part III), objective and quantitative measures of bradykinesia (Purdue Pegboard and timed gait), Leeds Dyspepsia Questionnaire, and PDQ-39 (a health-related quality of life questionnaire). RESULTS: 32.4[percnt] of PD patients were HP-positive. HP-positive patients were older (68.4±7.3 vs. 63.8±8.6 years, P=0.009) and had significantly worse motor outcomes; UPDRS Part III (34.0±13.0 vs. 27.3±10.0, P=0.006), Pegboard (6.4±3.3 vs. 8.0±2.7 pins; P=0.012) and timed gait (25.1±25.4 vs. 15.5±7.6 seconds; P=0.042). In multivariate analysis, HP status demonstrated significant main effects on UPDRS Part III and timed gait. The association between HP status and these motor outcomes varied according to age. Indigestion and burping were more common among HP-positive patients. PDQ-39 Summary Index scores did not differ between the two groups. CONCLUSIONS: This is the first and largest cross-sectional study to demonstrate an association between HP positivity and worse PD severity in relation to both motor and gastrointestinal symptoms. Properly designed treatment trials are needed to investigate the causal link between HP infection and PD, and the underlying mechanisms for this. Study Supported by: Malaysian Ministry of Higher Education grants for High-Impact Research (HIR), E000033 and UM.C/625/1/HIR/MOHE/CHAN/11-H-50001-00-A000025
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".