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Expression Profiles of miRNAs in Heart and Vessel

2010· book-chapter· en· W2286987053 on OpenAlexaff
Zhiguo Wang

Bibliographic record

VenueBENTHAM SCIENCE PUBLISHERS eBooks · 2010
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMicroRNA in disease regulation
Canadian institutionsUniversité de MontréalMontreal Heart Institute
Fundersnot available
KeywordsmicroRNACardiac function curveBiologyCardiac muscleFunction (biology)Computational biologyBioinformaticsInternal medicineAnatomyMedicineGeneticsGeneHeart failure

Abstract

fetched live from OpenAlex

To date, more than 5000 miRNAs have been identified in animals across the lowest and the highest species, some 800 of them are found in humans. To have better understanding of how miRNAs function in the heart, it is necessary to have an idea about which miRNAs exist in the heart. This chapter focuses on cardiovascular-expressed miRNAs or the miRNA profiles in heart and vessel. Specifically, the miRNAs existing in the heart will be introduced by categories: cardiac-specific, muscle-specific, cardiac-enriched, and other cardiac-expressed, in detail on their genomic locations and relative expression levels in normal cardiac tissues. Alterations of miRNA signature under various diseased states of the heart are succinctly described and the precautions in interpreting the profiling data are stated

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.283
Threshold uncertainty score0.778

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.239
Teacher spread0.228 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2010
Admission routes1
Has abstractyes

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