Stomatin-like protein 2: a link between T cell activation and mitochondrial function (35.19)
Bibliographic record
Abstract
Abstract During a study to characterize the proteome of lipid raft microdomains of activated human T cells we identified stomatin-like protein 2 (SLP-2). We have previously shown that T cell activation through the TCR leads to up-regulation of SLP-2 expression, which in turn correlates with enhanced T cell effector responses. Since in human T cells the major pool of SLP-2 is associated with mitochondria, we examined the function of this protein in mitochondria during T cell activation. Here, we report that up-regulation of SLP-2 expression increases mitochondrial mass and count. Such an effect correlates with an increase in the expression of the nuclear transcriptional co-activator PGC-1α, in lipid biosynthesis linked to mitochondrial membrane biogenesis, and in mitochondrial DNA replication. As expected, these changes translate into an increase in both cellular and mitochondrial ATP levels, higher mitochondrial uptake of calcium, and enhanced resistance to apoptosis through the intrinsic pathway. Based on these results we propose that SLP-2 expression is a key regulatory step for mitochondrial biogenesis and function in response to T cell activation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".