Analysis of downstream events of human Pax‐5B signalling in B lymphocytes
Bibliographic record
Abstract
The Pax‐5 gene, which codes for a potent transcription factor named BSAP, plays an important role in B lymphocyte development and oncogenesis. Aberrant expression of Pax‐5 has been associated with different cancer such as lymphomas, leukemia and testicular cancer. Under the control of two alternative promoters, Pax‐5 can simultaneously express two different forms (i.e. Pax‐5A and Pax‐5B). Through the use of a ribozyme‐based gene suppression system, we demonstrate that Pax‐5B is an important factor in the regulation of intracellular signalling cascades and elements leading to modulation of biological processes such as cellular proliferation, survival and apoptosis. More specifically, this study characterizes the implication of the hPD‐1 receptor, Bax/Bcl2 ratios and p53 in Pax‐5B‐mediated apoptosis. These findings bring new insight into autoimmune diseases and cancer processes in human B lymphocytes. Research support from New Brunswick Innovation Foundation and Canadian Institutes in Health Research and Atlantic Innovation Foundation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".