Prolonged amelioration of LV dysfunction after withdrawal of chronic CNS blockade of AT <sub>1</sub> receptors in rats with CHF post MI
Bibliographic record
Abstract
In rats post‐MI, LV dysfunction is attenuated by CNS AT 1 receptor blockade with icv infusion of losartan at doses which are ineffective when administered peripherally. The present study tested whether after withdrawal of the blockade these effects of icv losartan continue. As of 2 days after coronary artery ligation, Wistar rats were infused icv via osmotic minipumps with losartan (1 mg/kg/d) or vehicle, or injected sc daily with losartan (100 mg/kg/d), for 4 wks. Rats with sham ligation served as control. Echocardiography was performed at 4 wks. Two wks after withdrawal of losartan treatment, echo was repeated and LV function assessed with a Millar catheter. These results indicate that in Wistar rats, in contrast to general blockade specific CNS blockade of AT 1 receptors early post MI effectively ameliorates LV systolic dysfunction, and these effects remain for at least 2 weeks after withdrawal of icv losartan. Supported by a grant from Heart Stoke Foundation of Ontario.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".