Glycemic and Blood Pressure Responses to Acute Doses of Rebaudioside A, a Steviol Glycoside, in Subjects with Normal Glucose Tolerance or Type 2 Diabetes Mellitus
Bibliographic record
Abstract
Steviol glycosides, predominantly stevioside and rebaudioside A, extracted from the plant Stevia rebaudiana Bertoni, are used in several countries as food sweetening agents. This randomized, double‐blind, placebo‐controlled crossover trial examined the glycemic and blood pressure responses during meal tolerance tests to rebaudioside A consumed at three doses (500 mg, 750 mg, and 1000 mg) by men and women with normal glucose tolerance (n=45) or type 2 diabetes mellitus (n=48). Incremental areas under the concentration curves (pre‐meal to 240 min) for glucose, insulin, C‐peptide, and glucagon did not differ significantly for any dose of rebaudioside A tested vs. placebo or for all rebaudioside A doses combined vs. placebo. There were no significant differences between placebo and rebaudioside A in the effects on postprandial systolic or diastolic blood pressures. Rebaudioside A was well tolerated at all doses. These results suggest that acute consumption of up to 1000 mg of rebaudioside A has no clinically important acute effects on glucose homeostasis or blood pressure among individuals with normal glucose tolerance or type 2 diabetes mellitus. Funded by Cargill Corporation (Wayzata, MN).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".