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Record W2290161599 · doi:10.1191/1358863x06vm661xx

Vascular viewpoint

2006· article· en· W2290161599 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueVascular Medicine · 2006
Typearticle
Languageen
FieldMedicine
TopicPeripheral Artery Disease Management
Canadian institutionsToronto General HospitalUniversity of Toronto
Fundersnot available
KeywordsMedicineAmputationDuplex scanningClinical endpointSurgeryClaudicationIntermittent claudicationCritical limb ischemiaDuplex ultrasonographyStenosisPopulationQuality of life (healthcare)Randomized controlled trialCardiologyInternal medicineVascular diseaseArterial disease

Abstract

fetched live from OpenAlex

Question: Is duplex scanning superior to clinical vein graft surveillance with respect to amputation rates, quality of life, and cost following femoropopliteal or femorocrural vein bypass graft? Population: Between 1998 and 2001, patients from 29 centers in the UK and Europe who had a patent vein graft 30 days following femoropopliteal or femorocrural vein bypass surgery for critical ischemia, claudication or symptomatic popliteal aneurysms were recruited for the study. Methods and results: There were 592 patients included in this multicenter randomized controlled trial. Patients with patent vein grafts at 30 days were randomized to receive or not receive duplex surveillance in addition to clinical examinations and ankle-brachial indices at 6 weeks (time of recruitment), and 3, 6, 9, 12 and 18 months. Stenoses within grafts were defined as slow peak systolic velocity (<45 cm/s), or a ratio of peak systolic velocity in an area of stenosis to any other area within 2 cm of >2. The primary endpoints were time to amputation and time to vascular mortality (MI, CHF, arrhythmia or CVA). Secondary outcomes included graft patency (whether primary or secondary, assisted or unassisted), cost, and quality of life as measured by SF-36 and EuroQol. The primary endpoints were analyzed according to an intention-to-treat analysis using Cox-regression and Kaplan-Meier life tables, while secondary outcomes were analyzed by the Mann-Whitney test and a t-test. Approximately 11% of patients died during the study, while 12% withdrew (45% of which were due to amputations). There were significantly more diagnostic interventions in the clinical follow-up group (31% vs 22%, P = 0.01). Between the clinical follow-up and duplex groups, there was no difference in amputation rate (7% vs 7%) or vascular death rate (3% vs 4%). A greater proportion of patients in the clinical follow-up group had a stenosis in the graft identified at the end of the study (19% vs 12%, p = 0.04). There were no differences in Kaplan-Meier estimates of primary, primary assisted and secondary patency rates between the two groups at 18 months. No differences in quality of life as measured by SF-36 or EuroQol were detected between the two groups. The cost per patient was greater in the duplex group (US$ 1537 vs US$ 2406, p = 0.002). Conclusion: The authors conclude that surveillance with duplex scanning following femoropopliteal or femorocrural bypass was more costly, but did not result in lower amputation rates.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.344
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.238
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it