Exercise induces Hsp70 in endothelial cells of the coronary vasculature
Bibliographic record
Abstract
Exercise (EX) and heat‐shock (HS) both lead to increased myocardial content of the cardioprotective inducible isoform of the 70 kDa heat shock protein, (Hsp70). Twenty‐four hours after HS, myocardial Hsp70 is co‐localized with blood vessels, indicating a cell‐type specific response to this stress. The objective of the current study was to determine whether a similar localization of myocardial Hsp70 occurs post‐EX. Adult male Sprague Dawley rats were randomized into control (CON), EX (60 min treadmill running, 30 m/min) or HS (42°C, 15 min) groups. Left ventricles (LV) were harvested at 30 min and 24 hrs post‐treatment and analyzed for Hsp70 by both western blotting and confocal immunofluorescence microscopy. Both HS and EX resulted in significant increases in Hsp70 in LV homogenates. Under both conditions, confocal microscopy revealed a minor increase in Hsp70 in the myocytes compared to CON, but as early as 30 min post‐treatment there was a striking increase in endothelial localized Hsp70 that persisted for up to 24 hrs. These data support previous findings with HS and suggest that exercise results in a similar cell‐type specific induction of myocardial Hsp70. Consequently, the cardioprotective nature of exercise may lie in the Hsp70 mediated protection of coronary blood vessels. Supported by CIHR‐CCT‐83029 and NSERC‐8170‐05 RGPIN.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".