Bibliographic record
Abstract
Skin extracts from a number of British Columbia nudibranchs have proven to be a rich source of novel metabolites. This thesis describes the structural investigation of several of these compounds and includes some preliminary studies of their biosynthetic origin and physiological role. The unique diacylguanidine triophamine (75) has been isolated from Triopha catalinae and Polycera tricolor. Its structure was deduced by classical chemical methods and confirmed by an unambiguous synthesis. Anisodoris nobilis provided the odoriferous degraded sesquiterpene dihydroapof arnesal (15). The structure of aldehyde jL5 was assigned by interpretation of spectral data. Extracts of Archidoris mohtereyensis contain the diterpenoic acid glyceride 17, its two monoacetates 18 and 19, the drimane sesquiterpenoic acid glyceride 20 and its monoacetate 21, the monocyclof arnesic acid glyceride 22 and the glyceryl ether 23. These compounds were established by a combination of spectral analysis, chemical interconversion and/or single crystal X-ray diffraction analysis. The structure of a free diterpenoic acid found in only one collection of A. montereyensis, was also tentatively identified. The isomeric farnesic acid glyceride 27 in addition to glycerides 17, 18, 20, 22 and ether 23 have also been isolated from Archidoris odhneri. The drimenoic acid glyceride 20 and the glyceryl ether 23 exhibit antifeedant activity against fish. Biosynthetic studies showed that ¹⁴C labeled mevalonic acid is incorporated into the terpenoid portion of glycerides 17 and 20 by A. montereyensis and into the farnesic acid portion of glyceride 24 by Archidoris odhneri. Preliminary results suggest that triophamine (75) is synthesized in situ by T. catalinae and the drimane skeleton of albicanyl acetate (36) is biosynthesized by Cadlina luteomarginata.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".