Impact of hypertension and hormonal status on relaxation of the pudendal vasculature in aging female rats
Bibliographic record
Abstract
The prevalence of female sexual dysfunction (FSD) and cardiovascular disease increases with age. We examined the impact of hypertension and hormonal status on pudendal artery function, a key resistance vessel for blood flow to the genital tissue. We hypothesize that pudendal arteries from aged stroke prone hypertensive rats (SHRSP) have impaired endothelium‐ and soluble guanylyl cyclase (sGC)‐mediated relaxation. Ovariectomies (OVX) or sham surgeries were performed in 7 month old SHRSP and Wistar Kyoto (WKY) female rats. At 11 months of age, pudendal arteries were mounted and exposed to increasing concentrations of phenylephrine (PE), acetylcholine (ACh) and sGC agonist BAY 41‐2272 (+/− sGC antagonist, ODQ). Pudendal arteries from SHRSP exhibited greater contraction to PE and impaired ACh‐mediated relaxation. These differences were further exacerbated in SHRSP‐ and WKY‐OVX. All groups demonstrated equal pudendal artery relaxation to BAY 41‐2272. In the presence of ODQ, relaxation to BAY 41‐2272 was abolished in SHRSP+/−OVX; however inhibition was overcome in the WKY and reduced by 50% in WKY‐OVX. In aged hypertensives, pudendal artery relaxation via ACh and sGC‐mediated pathways is impaired and this abnormality may contribute to FSD in hypertension. (Funded by Heart & Stroke Foundation Canada and NIH)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".