The progesterone receptor antagonist mifepristone abolishes carotid sinus nerve response to hypoxia in rat pups.
Bibliographic record
Abstract
We tested the hypothesis that endogenous progesterone enhances peripheral chemoreceptors function in rat pups. Newborn rats have been treated with the progesterone receptor antagonist mifepristone (Mif) between postnatal days 3‐12 (70μg/g/day) and compared to control (Cont). We used the in‐vitro carotid body/carotid sinus nerve (CSN) preparation to record CSN activity (impulses/sec) in 12‐day‐old rats under normoxia (perfusion medium bubbled with 21%O 2 ‐5%CO 2 ), in response to hypoxia (5%O 2 ‐5%CO 2 ), or nicotine (mediator between carotid body type I cells and CSN terminals, 100μM) supefusion for 3‐4 minutes each. Baseline CSN firing frequency was similar between groups, at 2.7±0.3 in Cont and 2.6±0.3 Hz in Mif pups. At steady state hypoxic CSN activity increased to 7.5±0.9 Hz in Cont, but was left unchanged in Mif pups (3.0±0.5 Hz, p<0.0002 between groups). In response to nicotine superfusion, CSN firing activity increased to 10.8±1.9 Hz in Cont and to 6.1±3.3 Hz in Mif (p<0.04 between groups). We conclude that endogenous progesterone plays an important role in carotid body during postnatal development in rats. Founded by SickKids Foundation (XG07‐006)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".