Modification of the Adiponectin:Leptin Ratio May Underlie Obesity Dependent Prostate Cancer Progression
Bibliographic record
Abstract
Obesity and prostate cancer exhibit a statistical link, which may be due to the paracrine/endocrine cell cycle effects of the adipocyte‐derived peptides leptin (LEP) and adiponectin (ADIPO). ADIPO induced AMPK–dependent phosphorylation of p27 on T198 (T198‐P) and increased total p27 protein and adiponectin receptor (ADIPOR1) protein levels in androgen‐receptor (AR) negative PC3 prostate cancer cells. Conversely, LEP induced the opposite effects on AMPK, T198‐P p27, total p27 and ADIPOR1 protein levels. LEP and ADIPO also had opposing effects in AR‐positive LNCaP cells. As observed in breast cancer cells, LEP treatment overcame the effects of ADIPO on all proteins examined in a concentration‐dependent manner. Furthermore, ADIPO administration was able to counteract the effects of LEP on all proteins measured. Our data suggest that ADIPO and LEP exert antagonistic effects on prostate epithelial cell cycle regulation, and modification of the ADIPO:LEP ratio may be one of the important factors that underlie the molecular link between obesity and prostate cancer progression.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".