Effects of Neonicotinoids on Promoter-Specific Expression and Activity of Aromatase: Implications for the Development of Hormone-Dependent Breast Cancer
Bibliographic record
Abstract
Aromatase (CYP19) is the key enzyme in the biosynthesis of estrogens.In humans, it is expressed in a tissue-and promoter-specific manner.In hormone-dependent breast cancer, CYP19 is overexpressed through the activation of several additional promoters (PII, I.3 and I.7) that are normally inactive in the healthy mammary gland.In the normal mammary gland, low basal CYP19 expression is regulated by the I.4 promoter, which is also active in adipose tissue.Here, we highlight our recent study of the effects of neonicotinoid pesticides on the promoter-specific expression of CYP19 in various human in vitro models.We also discuss the implications of endocrine disruption by environmental chemicals for the development of hormone-dependent diseases, such as breast cancer.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".