Weekly paclitaxel treatment of patients with progressive platinum resistant epithelial ovarian cancer
Bibliographic record
Abstract
5137 Background: Paclitaxel administered on a weekly basis can have both an anti angioneogenesis and apoptotic inducing effects on cancer cells. We studied the activity of weekly Paclitaxel in patients with recurrent platinum resistant ovarian cancer and its effects on patients’ quality of life. Methods: Retrospective reviews of all patients with recurrent platinum resistant epithelial ovarian cancer treated with intravenous continuous weekly Paclitaxel (80mg/m2 for maximum of 24 weeks) were carried out. Evaluable endpoints were toxicities, response rates, and quality of life measurements. Quality of life was assessed using standard FACT-O questionnaire after the fourth weekly treatment. Median overall and progression free survival were estimated using Kaplan Meier method. Analysis of variance were used to compare mean Quality of Life scores between weekly Paclitaxel and other chemotherapy regimens using the existing institutional quality of life database. Results: Thirty-four patients were identified for review. The median line of chemotherapy administered as weekly Paclitaxel was three. The median platinum and taxane free interval were 7.6 months and 10.4 months respectively. Five patients (15%) reported grade 3 or 4 neurotoxicity or fatigue. The median nadir white blood count, haemoglobin, and platelet were 3.65, 99.50, and 224 during the course of treatment. At a median follow up of 7.3 months, fourteen patients (40%) had died. Twenty patients (61%) had a persistent decrease of their Ca125 by more than fifty percent from baseline value. Complete response was observed in three patients (8.8%) with another 14 patients showing partial response (41.2%) based on radiographic criteria. The median progression free survival was 6.10 months (95% CI: 3.81–8.39) and the median survival was 10.43 months (95% CI: 8.49–12.38) from the start of weekly treatment. Quality of Life assessments showed no significant differences between weekly Paclitaxel, Liposomal Doxorubicin, and Topotecan. Conclusions: Weekly Paclitaxel is a well-tolerated and active regimen in patients with recurrent platinum resistant ovarian cancer. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Bristol-Meyer Squibb
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".