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Record W2306906617 · doi:10.1038/ng.3562

Five endometrial cancer risk loci identified through genome-wide association analysis

2016· review· en· W2306906617 on OpenAlexfundno aff
Timothy Cheng, Deborah J. Thompson, Tracy A. O’Mara, Jodie N. Painter, Dylan M. Glubb, Susanne Flach, Annabelle Lewis, Juliet D. French, Luke Freeman-Mills, David N. Church, Maggie Gorman, Lynn Martin, Shirley Hodgson, Penelope M. Webb, John Attia, Elizabeth Holliday, Mark McEvoy, Rodney J. Scott, Anjali K. Henders, Nicholas G. Martin, Grant W. Montgomery, Dale R. Nyholt, Shahana Ahmed, Catherine S. Healey, Mitul Shah, Joe Dennis, Peter A. Fasching, Matthias W. Beckmann, Alexander Hein, Arif B. Ekici, Per Hall, Kamila Czene, Hatef Darabi, Jingmei Li, Thilo Dörk, Matthias Dürst, Peter Hillemanns, Ingo B. Runnebaum, Frédéric Amant, Stefanie Schrauwen, Hui Zhao, Diether Lambrechts, Jeroen Depreeuw, Sean C. Dowdy, Ellen L. Goode, Brooke L. Fridley, Stacey J. Winham, Tormund S. Njølstad, Helga B. Salvesen, Jone Trovik, Henrica M J Werner, Katie A. Ashton, Geoffrey Otton, Tony Proietto, Tao Liu, Miriam Mints, Emma Tham, Mulin Jun Li, Shun H. Yip, Junwen Wang, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Jonathan P Tyrer, Malcolm G. Dunlop, Richard S. Houlston, Claire Palles, John L. Hopper, Julian Peto, Anthony J. Swerdlow, Barbara Burwinkel, Hermann Brenner, Alfons Meindl, Hiltrud Brauch, Annika Lindblom, Jenny Chang-Claude, Fergus J. Couch, Graham G. Giles, Vessela N Kristensen, Angela Cox, Julie M. Cunningham, Paul D P Pharoah, Alison M. Dunning, Stacey L. Edwards, Douglas F. Easton, Ian Tomlinson, Amanda B. Spurdle

Bibliographic record

VenueNature Genetics · 2016
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicKruppel-like factors research
Canadian institutionsnot available
FundersNational Cancer InstituteCancer Council TasmaniaCancer Council QueenslandNational Health and Medical Research CouncilMedical Research CouncilU.S. Public Health ServiceQIMR Berghofer Medical Research InstituteStockholms Läns LandstingHelse VestKarolinska InstitutetCanadian Institutes of Health ResearchCancerfondenAgency for Science, Technology and ResearchHunter Medical Research InstituteVincent Fairfax Family FoundationNorges ForskningsrådBreast Cancer Research FoundationUniversity of CambridgeFred C. and Katherine B. Andersen FoundationAcademy of Medical SciencesWellcome TrustCancer Research UKUniversitetet i BergenNational Institute for Health and Care ResearchHaukeland UniversitetssjukehusRoswell Park Cancer InstituteFrancis Crick InstituteMayo Foundation for Medical Education and ResearchNational Institutes of HealthOvarian Cancer Research Fund
KeywordsGenome-wide association studyBiologyEndometrial cancerLocus (genetics)GeneticsSingle-nucleotide polymorphismGenetic associationAlleleCarcinogenesisSNPChromatinGeneCancerGenotype

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.364
Teacher spread0.343 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations97
Published2016
Admission routes1
Has abstractno

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