Th17 polarized cells from NOD mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes development (83.26)
Bibliographic record
Abstract
Abstract IL-17 producing T cells are regarded as potential pathogenic T cells in the induction of autoimmune diseases. Previously we have shown that injection of Mycobacteria containing products such as Bacille Calmette-Guerin (BCG) or Complete Freund Adjuvant (CFA), can prevent type 1 diabetes (T1D) in nonobese diabetic (NOD) mice. We injected NOD mice with mycobacterial products subcutaneously and analyzed the IL-17 producing cells from the draining lymph nodes and spleen by restimulating whole cell populations in vitro with or without IL-17 polarizing cytokines. Mice receiving CFA had a concomitant rise in the level of IL-17, IL-22, IL-10 and IFN-g in the draining lymph node and spleen. Adoptive transfer of splenocytes from CFA-injected NOD mice polarized with TGF-b plus IL-6 or IL-23 delayed the development of diabetes in recipient mice. IL-17 producing cells induced by CFA maintained their IL-17 producing ability in the recipient mice. Injection of CFA also changed the cytokine profile of cells in pancreatic tissue by increasing IL-17, IL-10 and IFN-g cytokine gene expression. Compared to wild type mice, injection of CFA into MyD88-/- mice drastically reduced but did not abolish the level of IL-17 in the lymphoid organs and pancreas indicating that the MyD88 pathway is a major pathway through which Mycobacteria exerts its effect. We suggest that the rise in the level of IL-17 after adjuvant therapy in NOD mice has a protective effect on T1D development.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".