Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
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- Teacher spread
- 0.221 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Aged haematopoietic stem cells (HSCs) generate more myeloid cells and fewer lymphoid cells compared with young HSCs, contributing to decreased adaptive immunity in aged individuals. However, it is not known how intrinsic changes to HSCs and shifts in the balance between biased HSC subsets each contribute to the altered lineage output. Here, by analysing HSC transcriptomes and HSC function at the single-cell level, we identify increased molecular platelet priming and functional platelet bias as the predominant age-dependent change to HSCs, including a significant increase in a previously unrecognized class of HSCs that exclusively produce platelets. Depletion of HSC platelet programming through loss of the FOG-1 transcription factor is accompanied by increased lymphoid output. Therefore, increased platelet bias may contribute to the age-associated decrease in lymphopoiesis.
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The record
- Venue
- Nature Communications
- Topic
- Hematopoietic Stem Cell Transplantation
- Field
- Medicine
- Canadian institutions
- —
- Funders
- Institute of Circulatory and Respiratory HealthBiotechnology and Biological Sciences Research CouncilEuropean CommissionMedical Research CouncilKay Kendall Leukaemia FundWellcome Trust
- Keywords
- HaematopoiesisStem cellLymphopoiesisBiologyPlateletMyeloidTranscriptomePriming (agriculture)Cell biologyImmunologyStem cell factorGeneticsGeneGene expression
- Has abstract in OpenAlex
- yes