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Record W2309377233 · doi:10.1093/hmg/ddw092

GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer

2016· review· en· W2309377233 on OpenAlexaff
Maxine Chen, Tracy A. O’Mara, Deborah J. Thompson, Jodie N. Painter, John Attia, Amanda Black, Louise A. Brinton, Stephen J. Chanock, Chu Chen, Timothy Cheng, Linda S. Cook, Marta Crous‐Bou, Jennifer A. Doherty, Christine M. Friedenreich, Montserrat García‐Closas, Mia M. Gaudet, Maggie Gorman, Christopher A. Haiman, Susan E. Hankinson, Patricia Hartge, Brian E. Henderson, Shirley Hodgson, Pamela L. Horn‐Ross, David J. Hunter, Loı̈c Le Marchand, Xiaolin Liang, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony Magliocco, Lynn Martin, Mark McEvoy, Sara H. Olson, Irene Orlow, Loreall Pooler, Jennifer Prescott, Radhai Rastogi, Timothy R. Rebbeck, Harvey A. Risch, Carlotta Sacerdote, Veronica Wendy Setiawan, Rodney J. Scott, Xin Sheng, Xiao‐Ou Shu, Constance Turman, David Van Den Berg, Zhaoming Wang, Noel S. Weiss, Nicholas Wentzensen, Lucy Xia, Yong‐Bing Xiang, Hannah Yang, Herbert Yu, Wei Zhang, Paul D.P. Pharoah, Alison M. Dunning, Ian Tomlinson, Douglas F. Easton, Peter Kraft, Amanda B. Spurdle, Immaculata De Vivo

Bibliographic record

VenueHuman Molecular Genetics · 2016
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Canadian institutionsAlberta Health Services
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Cancer InstituteFrancis Crick InstituteCancer Research UKWellcome Trust
KeywordsGenome-wide association studyEndometrial cancerLocus (genetics)Genetic predispositionMalignancyGenetic associationGeneticsMeta-analysisOncologyBiologyDiseaseMedicineCancerBioinformaticsInternal medicineSingle-nucleotide polymorphismGenotypeGene

Abstract

fetched live from OpenAlex

, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.845
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.005
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.106
GPT teacher head0.397
Teacher spread0.292 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations30
Published2016
Admission routes1
Has abstractyes

Explore more

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