Pediatric Staphylococcus aureus Infections: Impact of Methicillin Resistance at a Canadian Center
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) causes a wide spectrum of potentially serious infections in children. This study describes the evolving experience with S. aureus infections at a Canadian tertiary pediatric care center serving a wide geographic area. DESIGN: In this two-component study, a retrospective review of infection control databases for MRSA infection was conducted, along with a prospective component for 1 year during which all community-onset S. aureus infections were identified. Cases with methicillin resistance and susceptibility were compared. RESULTS: Review of infection control database records showed 239 unique infections, with steady increases over time. Common pulsed-field gel electrophoresis types included Canadian MRSA-7 and Canadian MRSA-10. During the 1-year prospective component, 210 clinical infections were identified, with MRSA isolated in 41%. Patients with MRSA were significantly younger than those with methicillin-susceptible isolates (4.9 vs 7.7 years, P < 0.001). The most common presentations were soft tissue infections in the emergency department, with a degree of inappropriate antimicrobial use. CONCLUSIONS: MRSA contributed to a significant proportion of S. aureus infections at a large Canadian tertiary care center. Ample opportunities exist to develop stewardship protocols, especially for the management of soft tissue infections in outpatients.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it