Bibliographic record
Abstract
PURPOSE OF REVIEW: Changes in redox state clearly play a role in airway inflammation and mucus rheology. Furthermore CFTR (cystic fibrosis transmembrane conductance regulator), the defective protein in cystic fibrosis (CF), not only is regulated by redox state but also directly modulates the epithelial redox environment through transepithelial flux of glutathione. The purpose of this review is to explore the potential therapeutic interest of antioxidant molecules in CF. RECENT FINDINGS: Several antioxidants have been shown to have mucolytic and anti-inflammatory properties. Some antioxidants such as zinc and vitamin C may also help increase epithelial chloride secretion through CFTR-dependent and independent pathways. Other antioxidants are showing promise in helping CFTR mobilization to plasma membranes. SUMMARY: The many levels of potential application offered by antioxidants make this class of molecules one of the promising areas of therapeutic development for CF. Several redox-modulating agents have a high likelihood of providing useful approaches for the treatment of many aspects of CF airway disease.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.010 | 0.006 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".