Assessment of the early regenerative therapeutic response in graft versus host disease using high definition technology with virtual i-Scan chromoendoscopy
Bibliographic record
Abstract
The gastrointestinal tract is the second most commonly involved organ system in graft versus host disease (GvHD) following allogeneic stem cell transplantation, and its involvement is associated with a worse prognosis [1] [2]. White light endoscopy findings are nonspecific and often unhelpful in the diagnosis of GvHD and evaluation of its response to therapy. Conventional histological examination of intestinal biopsy samples still represents the gold standard in GvHD diagnosis [3]. Moreover, after allogeneic stem cell transplantation, it could be potentially dangerous to carry out multiple biopsies and may require transfusion of erythrocytes, platelets, or coagulation factors. Here, we describe novel endoscopic findings associated with healing of the colonic mucosa in a patient with GvHD, obtained by high definition (HD +) technology with i-Scan virtual chromoendoscopy (Pentax Medical, Tokyo, Japan).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".