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Record W2313648293 · doi:10.51847/hrmskdz

10.51847/HrMskdZ

2000· article· en· W2313648293 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

venuePublished in a venue whose home country is Canada.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueTime to knit · 2000
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicFungal Plant Pathogen Control
Canadian institutionsnot available
Fundersnot available
KeywordsLanosterolAzoleBenzimidazoleFluconazoleKetoconazoleChemistryDemethylaseCytochrome P450SterolPharmacologyEnzymeAntifungalMicrobiologyBiologyBiochemistryOrganic chemistryCholesterol

Abstract

fetched live from OpenAlex

Fungal infections are increasing rapidly due to an increase in number of immuno-compromised hosts. Azoles are first line drugs for treatment of fungal infections due to their high therapeutic index but development of resistance due to extensive use of azoles and toxicity has significantly reduced the efficacy of azole antifungal agents and led to the search for new azoles. Azoles act by competitive inhibition of cytochrome P 450 (CYP450) enzyme, Lanosterol 14α-demethylase a key enzyme in b

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.986
Threshold uncertainty score0.134

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.9940.980

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.148
Teacher spread0.142 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it