Temporal and Geographic Evolution of Longstanding Crohn’s Disease Over More Than 50 Years
Bibliographic record
Abstract
Data on the natural history of longstanding Crohn's disease are very limited. After searching a clinical database of over 1000 patients with Crohn's disease, it was determined that eight patients (five women, three men) had disease documented for over 50 years. In spite of complex histories with either stricturing or penetrating complications, all currently have either no symptoms or minimal disease activity, often without the need for ongoing pharmacological treatment. Most significantly, their clinical courses were all characterized by prolonged asymptomatic periods, often for more than a decade, before the recurrence of symptomatic disease. Pathological findings in all patients revealed granulomatous inflammatory disease, often recurring intermittently over many decades. Moreover, the location of the findings implied that the disease has a tendency to evolve, not only in a temporal dimension, but also extending geographically within the gastrointestinal tract. These clinical and pathological features in longstanding Crohn's disease suggest that recurring or multiple discrete initiating events, rather than a single initiating event, could be involved in the etiology and pathogenesis of Crohn's disease.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".