Structural insight into<i>Neisseria meningitidis</i>PorB during pathogenesis
Bibliographic record
Abstract
PorB is the second most prevalent outer membrane protein in Neisseria meningitidis. PorB is required for bacterial survival and neisserial pathogenesis, but is also able to elicit a Toll-like receptor mediated host immune response. During infection, PorB can integrate into host cell mitochondria and likely binds mitochondrial ATP, which is thought to be important for cellular apoptosis. We have determined the x-ray crystal structure of PorB at 2.3 resolution. Structural analysis and co-crystallization with substrate molecule suggest three distinct putative solute translocation pathways (non-slective cation, non-selective anion and sugar specific) through the channel pore. Co-crystallization with the ATP analog AMP-PNP suggests that binding of nucleotides regulates these translocation pathways both by partial occlusion of the pore and by restricting the motion of a putative voltage gating loop. PorB, located on the surface of N. meningitidis, can be recognized by receptors of the host innate immune system during infection. Features of PorB suggest that Toll-like receptor mediated recognition of outer membrane proteins may be initiated by a non-specific electrostatic attraction.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".