Efficacy of instillations with chemotherapy or immunotherapy following endoscopic resection for upper tract urothelial carcinoma
Bibliographic record
Abstract
Although nephroureterectomy with a bladder cuff remains the gold-standard approach to upper tract urothelial carcinoma (UTUC), the relative ease by which local control can be achieved for non-muscle-invasive bladder urothelial carcinoma keeps prompting us to look into less radical and invasive methods of treating UTUC. The success of transurethral bladder tumor resection followed by intravesical therapy in controlling noninvasive bladder cancer has been firmly established. However, owing to the scarcity of patients with UTUC, there are only a few reports on the efficacy of percutaneous or endoscopic resection followed by instillation with chemotherapy or immunotherapy for UTUC, most of which have extrapolated data from bladder cancer in deciding on treatment regimens. The following manuscript portrays a comprehensive review of the literature on upper tract instillations in patients with UTUC.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.004 | 0.002 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".