sbv IMPROVER Diagnostic Signature Challenge
Bibliographic record
Abstract
Evaluating the performance of computational methods to analyze high throughput data are an integral component of model development and critical to progress in computational biology. In collaborative-competitions, model performance evaluation is crucial to determine the best performing submission. Here we present the scoring methodology used to assess 54 submissions to the IMPROVER Diagnostic Signature Challenge. Participants were tasked with classifying patients’ disease phenotype based on gene expression data in four disease areas: Psoriasis, Chronic Obstructive Pulmonary Disease, Lung Cancer, and Multiple Sclerosis. We discuss the criteria underlying the choice of the three scoring metrics we chose to assess the performance of the submitted models. The statistical significance of the difference in performance between individual submissions and classification tasks varied according to these different metrics. Accordingly, we consider an aggregation of these three assessment methods and present the approaches considered for aggregating the ranking and ultimately determining the final overall best performer.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".