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Record W2317248708 · doi:10.1103/physreve.85.021914

Neural population densities shape network correlations

2012· article· en· W2317248708 on OpenAlexafffund
Jérémie Lefebvre, Theodore J. Perkins

Bibliographic record

VenuePhysical Review E · 2012
Typearticle
Languageen
FieldNeuroscience
TopicNeural dynamics and brain function
Canadian institutionsOttawa Hospital
FundersFonds Québécois de la Recherche sur la Nature et les Technologies
KeywordsExcitatory postsynaptic potentialStatistical physicsPopulationAsymmetryStimulus (psychology)CorrelationInhibitory postsynaptic potentialAsynchronous communicationSensory systemMathematicsPhysicsBiological systemComputer scienceNeuroscienceBiologyQuantum mechanics

Abstract

fetched live from OpenAlex

The way sensory microcircuits manage cellular response correlations is a crucial question in understanding how such systems integrate external stimuli and encode information. Most sensory systems exhibit heterogeneities in terms of population sizes and features, which all impact their dynamics. This work addresses how correlations between the dynamics of neural ensembles depend on the relative size or density of excitatory and inhibitory populations. To do so, we study an apparently symmetric system of coupled stochastic differential equations that model the evolution of the populations' activities. Excitatory and inhibitory populations are connected by reciprocal recurrent connections, and both receive different stimuli exhibiting a certain level of correlation with each other. A stability analysis is performed, which reveals an intrinsic asymmetry in the distribution of the fixed points with respect to the threshold of the nonlinearities. Based on this, we show how the cross correlation between the population responses depends on the density of the inhibitory population, and that a specific ratio between both population sizes leads to a state of zero correlation. We show that this so-called asynchronous state subsists, despite the presence of stimulus correlation, and most importantly, that it occurs only in asymmetrical systems where one population outnumbers the other. Using linear approximations, we derive analytical expressions for the root of the cross-correlation function and study how the asynchronous state is impacted by the model's parameters. This work suggests a possible explanation for why inhibitory cells outnumber excitatory cells in the visual system.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.048
GPT teacher head0.312
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2012
Admission routes2
Has abstractyes

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Same venuePhysical Review ESame topicNeural dynamics and brain functionFrench-language works237,207