Transient Pupil Dilation after Subsaccadic Microstimulation of Primate Frontal Eye Fields
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Pupillometry provides a simple and noninvasive index for a variety of cognitive processes, including perception, attention, task consolidation, learning, and memory. The neural substrates by which such cognitive processes influence pupil diameter remain somewhat unclear, although cortical inputs to the locus coeruleus mediating arousal are likely involved. Changes in pupil diameter also accompany covert orienting; hence the oculomotor system may provide an alternative substrate for cognitive influences on pupil diameter. Here, we show that low-level electrical microstimulation of the primate frontal eye fields (FEFs), a cortical component of the oculomotor system strongly connected to the intermediate layers of the superior colliculus (SCi), evoked robust pupil dilation even in the absence of evoked saccades. The magnitude of such dilation scaled with increases in stimulation parameters, depending strongly on the intensity and number of pulses. Although there are multiple pathways by which FEF stimulation could cause pupil dilation, the timing and profile of dilation closely resembled that evoked by SCi stimulation. Moreover, pupil dilation evoked from the FEFs increased when presumed oculomotor activity was higher at the time of stimulation. Our findings implicate the oculomotor system as a potential substrate for how cognitive processes can influence pupil diameter. We suggest that a pathway from the frontal cortex through the SCi operates in parallel with frontal inputs to arousal circuits to regulate task-dependent modulation of pupil diameter, perhaps indicative of an organization wherein one pathway assumes primacy for a given cognitive process. SIGNIFICANCE STATEMENT: Pupillometry (the measurement of pupil diameter) provides a simple and noninvasive index for a variety of cognitive processes, offering a biomarker that has value in both health and disease. But how do cognitive processes influence pupil diameter? Here, we show that low-level stimulation of the primate frontal eye fields can induce robust pupil dilation without saccades. Pupil dilation scaled with the number and intensity of stimulation pulses and varied with endogenous oculomotor activity at the time of stimulation. The oculomotor system therefore provides a plausible pathway by which cognitive processes may influence pupil diameter, perhaps operating in conjunction with systems regulating arousal.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it