A case of Cronkhite-Canada syndrome treated by steroid pulse therapy
Bibliographic record
Abstract
A 47-year-old man visited our hospital with the chief complaints of diarrhea, dysgeusia, alopecia and onychodystrophy. Endoscopic examinations revealed an edematous and reddish mucosa and many polypoid lesions in the stomach and colon. Cronkhite-Canada syndrome was diagnosed and the patient was treated with intravenous prednisolone. The symptoms improved gradually, however, remission was not achieved. At one month after treatment, the serum albumin level still persisted. We then decided to administer steroid pulse therapy. With this therapy, the symptoms improved dramatically, and steroid maintenance therapy was initiated with betamethasone, which has a longer half-life than prednisolone. The patient’s condition improved, and repeat endoscopy revealed improvement of the polypoid lesions and mucosal inflammation. This case indicates that steroid pulse therapy may be useful for at least a proportion of patients with Cronkhite Canada syndrome, and may also be useful for helping in deciding the treatment policy.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".