Effects of astrocytic mechanisms on neuronal hyperexcitability
Bibliographic record
Abstract
While originally astrocytes have been thought to only act as support to neurons, recent studies have implicated them in multiple active roles, including the ability to moderate or alter neuronal firing patterns and to possibly be involved in both the prevention and propagation of epileptic seizures. In this study we propose a new model to incorporate pyramidal cells and interneurons (a common neural circuit in CA3 hippocampal slices) as well as a model of astrocyte. As both potassium and calcium ions have been shown to potentially affect neuronal hyperexcitability, the astrocytic model has both mechanisms--the clearance of potassium through potassium channels (such as KIR, KDR and sodium-potassium pump), and the influence of astrocyte in the synapse (forming the tripartite synapse with calcium-glutamate interactions). Preliminary findings of the model results show that when potassium conductances in the astrocyte are decreased, it results in the accumulation of extracellular potassium, leading to both spontaneous discharges and depolarization block, while the alteration of normal calcium response in the astrocyte can lead to just hyperexcitable conditions without the depolarization block.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".