Structure and biological activity of a cyclic lipodepsipeptide phaeofungin discovered with the Candida albicans fitness test
Bibliographic record
Abstract
Phaeofungin, a cyclic lipodepsipeptide, was isolated from a fermentation a Phaeosphaeria sp. (Phaeosphaeriaceae) from Spain. Antibiosis of the extract was recognized in an assay for C. albicans cell-wall perturbing agents. The extracts were chemogenomically assayed in the C. albicans fitness test (CaFT) that profiles the activities of antifungal agents. The CaFT profile overlapped with, but was differentiated from that of an antifungal lipodepsipeptide, phomafungin. Differences were confirmed when structure of phaeofungin was elucidated by spectroscopic methods including HRFTMS and 2D NMR. The amino acid identity and configuration were confirmed by acid hydrolysis followed by Marfey's derivatization. The antifungal activities of both lipodepsipeptides demonstrated phaeofungin synergizes with aureobasidin A and caspofungin leading to ATP leakage from cells of C. albicans.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".