Structure and biological activity of a cyclic lipodepsipeptide phaeofungin discovered with the Candida albicans fitness test
Bibliographic record
Abstract
Phaeofungin, a cyclic lipodepsipeptide, was isolated from a fermentation a Phaeosphaeria sp. (Phaeosphaeriaceae) from Spain. Antibiosis of the extract was recognized in an assay for C. albicans cell-wall perturbing agents. The extracts were chemogenomically assayed in the C. albicans fitness test (CaFT) that profiles the activities of antifungal agents. The CaFT profile overlapped with, but was differentiated from that of an antifungal lipodepsipeptide, phomafungin. Differences were confirmed when structure of phaeofungin was elucidated by spectroscopic methods including HRFTMS and 2D NMR. The amino acid identity and configuration were confirmed by acid hydrolysis followed by Marfey's derivatization. The antifungal activities of both lipodepsipeptides demonstrated phaeofungin synergizes with aureobasidin A and caspofungin leading to ATP leakage from cells of C. albicans .
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".