Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
AUA Annual MeetingDAVID M. LATINI, PHD, noted that although large databases may be sufficient for registry studies, the registries are not set up to ask about sexual orientation—”They don't ask people about the gender of their partner. In large disease registry studies that report results for prostate cancer for quality of life, we actually have gay men in the studies but we just don't know who they are.”WASHINGTON, DC—Gay men have a tougher time dealing with the aftermath of prostatectomy than heterosexual men do, researchers reported here at the American Urological Association Annual Meeting. The physical as well as psychosocial quality of life of gay men appears to suffer more acutely the side effects of the cancer treatment compared with the situation for straight men, said David M. Latini, PhD, Assistant Professor of Urology & Psychiatry at Baylor College of Medicine and Chief of the Design and Analysis Program at the VA Health Science Research and Development Center of Excellence. “We find that men in our sample are significantly different in almost every domain of quality of life, and these differences are large enough to not just be statistically significant but are also clinically relevant,” Dr. Latini said at a news briefing. Consistent Negative Results “These are important differences that we think people should know about,” he said. He and colleagues used a battery of studies to determine the health-related quality of life for gay men compared with a historical control group. Those results showed that gay men fared consistently worse than the comparison group. For example: The mean urinary function score for the 90 gay men who completed that part of the questionnaire was 67.2 compared with 86.5 in the comparison sample of 252 men. Dr. Latini said this may relate to urinary leakage and the number of pads men may have to use following prostatectomy. The mean urinary “bother” score for the 90 gay men who completed that part of the questionnaire was 68.9 compared with 75.8 in the comparison sample. “Bother,” Dr. Latini explained, might be urinary incontinence episodes that are not particularly a concern as part of activities of daily living. The mean sexual function score for the 89 gay men who completed that part of the questionnaire was 38.7 vs 29.5 in the comparison sample—sexual functioning considers erectile dysfunction, ability to perform intercourse, the number of erections, and other aspects of sexual activity. The mean sexual bother score for the 89 gay men who completed that part of the questionnaire was 40.1 vs 41.1 in the comparison sample. The mean bowel function score for the 90 gay men who completed that part of the questionnaire was 77.6 vs 87.9 in the comparison sample. The mean bowel bother score for the 90 gay men who completed that part of the questionnaire was 77.5 vs 85.3 in the comparison sample. The mean hormonal function score for the 85 gay men who completed that part of the questionnaire was 73.5 vs 84.0 in the comparison sample—this test relates to depression, loss of hair, development of gynecomastia, etc., he said. The mean hormonal bother score for the 90 gay men who completed that part of the questionnaire was 52.4 vs 88.7 in the comparison sample. The mean Short Form-36 Mental Composite Summary score for the 86 gay men who completed that part of the questionnaire was 43.9 vs 51.9 in the comparison sample. The mean Short Form-36 Physical Component Summary score for the 86 gay men who completed that part of the questionnaire was 48.3 vs 48.9 in the comparison sample. The mean “fear of recurrence” score for the 91 gay men who completed that part of the questionnaire was 49.2 vs 20.0 in the comparison sample. The mean ejaculatory function score for the 89 gay men who completed that part of the questionnaire was 4.5 vs 12.4 in the comparison sample. Drug May Lack Impact Dr. Latini also noted that many gay men, especially the insertive partner, had severe sexual quality-of-life disturbances because the aftermath of prostatectomy was not helped as much by phosphodiesterase-5 inhibitor medication that allows men with erectile dysfunction to function sexually. “For gay men this is a particularly difficult area,” he explained. “The phosphodiesterase-5 inhibitors were created with an endpoint in the trials of vaginal penetration. We know that an erection has to be firmer to penetrate someone anally. So for sexual intercourse between two males, these medications are usually not sufficient. “Many of the guys in our sample are struggling with that, and are forced, if they want to remain the insertive partner to go to other more invasive treatments.” The moderator of the news conference, Tomas Griebling, MD, MPH, Professor of Urology at the University of Kansas Medical Center, said, “From my perspective, one of the biggest things we learned from these results is that gay men and straight men experience prostate cancer and the effects of prostate cancer in different ways. For gay men the negative impact on their overall health-related quality of life is more severe. It's more profound.” 3%-5%TOMAS GRIEBLING, MD, MPH: “When we were selecting items for the press program, this abstract was unanimously selected. This is a population that is very underrepresented in research and particularly in urological research.”Dr. Latini said that since gay men constitute about 3% to 5% of the total male population of the United States, that also means that about 3% to 5% of the 200,000 men diagnosed with prostate cancer are gay and that 3% to 5% of the men living with prostate cancer are gay men. “So we are talking about a fairly substantial subsample of men and yet there is really nothing in the literature” that had looked at the problem beyond a couple of small studies. Filling a Research Void He and his colleagues attempted to start filling in this research gap. Using the Internet and handing out flyers in Toronto and Houston and contacting patients in a clinic in San Francisco, Dr. Latini was able to assemble a convenience sample of 92 men for the study. “We used some validated questionnaires used in many other prostate cancer studies as well as a number of scales that are unique to gay men,” he said. He noted that although large databases may be sufficient for registry studies, the registries are not set up to ask about sexual orientation. “They don't ask people about the gender of their partner,” he said. “In large disease registry studies that report results for prostate cancer for quality of life we actually have gay men in the studies, but we just don't know who they are.” Continuing Project Dr. Latini said the results presented at the AUA meeting are just the beginning of his research project. He and his research team also collected data from about two dozen of the partners of the 92 men who self–selected for the survey. They are continuing to review their data on how prostatectomy may affect the partners of gay men. He said the research is also delving into the characteristics that show how some men are coping with the aftermath of prostatectomy compared with those men who are not doing as well. “Many gay men have had bad experiences with the health care system and it is difficult for them to be open with their urologist about the fact that they are gay,” Dr. Latini noted. Similarly, he said, gay men have difficulty being open in groups of non-gay men in discussing sexual activities; they may not have the support of their male partner being in the room with them in the same way that a heterosexual couple can. Additional Studies Required “More research is needed to determine what steps we can take to diminish these impacts,” Dr. Griebling said. “When we were selecting items for the press program, this abstract was unanimously selected. This is a population that is very underrepresented in research and particularly in urological research. “This is very important preliminary data, and the results show there is a significant issue here. It lays the groundwork for the fact that we need well-designed, prospective trials that address these issues, specifically within the context of sexual orientation of the patients and their partners.” Dr. Griebling noted that for many years men—regardless of sexual orientation—were reluctant to discuss the sexual and physical aspects of post-prostatectomy functioning. “The take home message,” he said, “is that straight men now may be more willing to talk about this problem with their physician, but gay men may not reveal their sexual orientation to their treating provider.”
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it