The substrate recognition and the catalytic reaction mechanisms of D-3-hydroxybutyrate dehydrogenase
Bibliographic record
Abstract
Poster Sessions is grown on acetate, IDH is in its inactive phosphorylated form, thus inhibiting Krebs' cycle.Alternatively, a change of carbon source to glucose or pyruvate results in the activation of IDH by dephosphorylation, and the initiation of Krebs' cycle.The function of AceK and its involvement in the regulation of Krebs' cycle and the glyoxylate bypass is well-characterized, but its structural and mechanistic qualities have remained relatively unknown.The determination of the crystal structure could provide confirmation of the function of AceK by identifying the various kinase, phosphatase and ATPase domains and insights into the coordination of the kinase and phosphatase activity of AceK.Of note, it is currently unknown how, or if at all, the active site changes conformation as it switches between kinase and phosphatase activity.Three Acek crystal forms were obtained and SAD datasets were collected at CHESS and BNL synchrotron source.The AceK structure is determined at 2.6 Å.The overall AceK structure displays a typical eukaryotic kinase folding.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".