Synthesis of 1‐Bromopyrene and 1‐Pyrenecarbaldehyde
Bibliographic record
Abstract
Abstract The article discusses synthesis of 1‐bromopyrene and 1‐pyrenecarbaldehyde. Due to the useful photophysical attributes of pyrene, it is a desirable component of many functional materials. Thus, 1‐bromopyrene is a key building block for a large portion of the chemical community. The first synthesis of 2 was described in 1937 by Lock, via the bromination of 1. Similar approaches have since been described using reagents such as NBS, CuBr and HBr with H 2 O The use of column chromatography in these protocols, however, limits the reaction scale. Fulfilling the demand for 1‐bromopyrene in larger amounts, a simple and chromatography free procedure has been reported in 1968 by Gumprecht. Unfortunately, this procedure require the use of CCl 4 as solvent, which has been prohibited in many countries due to toxicological and environmental concerns. Thus, there is considerable demand for a procedure with similar synthetic utility that does not require CCl 4 or column chromatography.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".