Synthesis and Self-Assembly of Stimuli-Responsive Poly(2-(dimethylamino) ethyl methacrylate)-<i>block</i>-fullerene (PDMAEMA-<i>b</i>-C<sub>60</sub>) and the Demicellization Induced by Free PDMAEMA Chains
Bibliographic record
Abstract
Well-defined poly(2-(dimethylamino) ethyl methacrylate)-block-fullerene [60] ((PDMAEMA)-b-C(60)) with a galactose targeting moiety was prepared by atom-transfer radical polymerization (ATRP). This copolymer was designed for possible use as a targeted drug carrier. The chemical composition and the self-assembly behavior were characterized using different techniques, including GPC, NMR, UV, and DLS. The self-assembly of the galactose-functionalized PDMAEMA-b-C(60) structure in aqueous solutions was investigated using dynamic light scattering (DLS) under different pH conditions. At pH 3 and 10, the DLS results showed the presence of both polymeric micelles and unimers. However, a smaller R(h) was observed at pH 10 than at pH 3 because of electrostatic repulsion at low pH values. In addition, free PDMAEMA chains induced the demicellization of self-assembled nanostructures caused by the formation of a charge-transfer complex between PDMAEMA and C(60.) This phenomenon offers possible applications for free-polymer-triggered drug release.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".