Microvilli expressed on glioma cells keep cytotoxic cells at a distance
Bibliographic record
Abstract
Glioblastoma multiforme (GBM), the most frequent primary brain tumor in adults, carries a particularly poor prognosis despite aggressive treatment approaches. A possible explanation for treatment failure resides in the capacity of glioma cells to infiltrate the brain parenchyma and therefore escape surgical removal and radiation exposure. One of the most promising novel strategies in glioma therapy is to use the patient's immune system to attack the tumor. Cytotoxic effector cells are crucial components of the immune system to fight cancers; genetically modified cytotoxic T cells that recognize tumor antigens can destroy cancer cells. Glioma cells, on the other hand, use several strategies to escape this immunological attack. In a recent study, Hoa and colleagues reported that cell surface expression of microvilli protects gliomas from being killed by cytotoxic effector cells.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.005 | 0.003 |
| Insufficient payload (model declined to judge) | 0.015 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".